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• W2023969923 abstract "One exercise session can improve subsequent insulin-stimulated glucose uptake by skeletal muscle in healthy and insulin-resistant individuals. Our first aim was to determine whether a brief (2 weeks) high-fat diet (HFD) that caused muscle insulin resistance would activate the mammalian target of rapamycin complex 1 (mTORC1) and/or inhibitor of κB kinase/nuclear factor κB (IKK/NF-κB) pathways, which are potentially linked to induction of insulin resistance. Our second aim was to determine whether acute exercise that improved insulin-stimulated glucose uptake by muscles would attenuate activation of these pathways. We compared HFD-fed rats with rats fed a low-fat diet (LFD). Some animals from each diet group were sedentary and others were studied 3 h postexercise, when insulin-stimulated glucose uptake was increased. The results did not provide evidence that brief HFD activated either the mTORC1 (including phosphorylation of mTOR Ser2448 , TSC2 Ser939 , p70S6K Thr412 , and RPS6 Ser235/236 ) or the IKK/NF-κB (including abundance of IκBα or phosphorylation of NF-κB Ser536 , IKKα/β Ser177/181 , and IκB Ser32 ) pathway in insulin-resistant muscles. Exercise did not oppose the activation of either pathway, as evidenced by no attenuation of phosphorylation of key proteins in the IKK/NF-κB pathway (NF-κB Ser536 , IKKα/β Ser177/181 , and IκB Ser32 ), unaltered IκBα abundance, and no attenuation of phosphorylation of key proteins in the mTORC1 pathway (mTOR Ser2448 , TSC2 Ser939 , and RPS6 Ser235/236 ). Instead, exercise induced greater phosphorylation of 2 proteins of the mTORC1 pathway (PRAS40 Thr246 and p70S6K Thr412 ) in insulin-stimulated muscles, regardless of diet. Insulin resistance induced by a brief HFD was not attributable to greater activation of the mTORC1 or the IKK/NF-κB pathway in muscle, and exercise-induced improvement in insulin sensitivity was not attributable to attenuated activation of these pathways in muscle." @default.
• W2023969923 created "2016-06-24" @default.
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• W2023969923 date "2015-03-01" @default.
• W2023969923 modified "2023-09-27" @default.
• W2023969923 title "Effects of a brief high-fat diet and acute exercise on the mTORC1 and IKK/NF-κB pathways in rat skeletal muscle" @default.
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• W2023969923 doi "https://doi.org/10.1139/apnm-2014-0412" @default.
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