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- W2023971220 abstract "Background: Hepatitis B virus (HBV) is associated with acute and chronic infections of the liver and can lead to advanced liver diseases like cirrhosis and hepatocellular carcinoma (HCC). Information about microRNA (miRNA) mediated regulation of viral infections is just emerging. During HBV infection, perturbations of cell cycle regulating miRNA expression might have significant correlation with development with HCC. Aim: Our aim is to assess the status of miRNA-145 expression in HBV-infected HCC. Methods: HepG2 cells transiently transfected with HBV plasmid. RNA and the protein were extracted following time kinetics. Expression of miRNA-145 and its target mRNA mitogen-activated protein kinase 3 (MAP3K) were measured by real time PCR and target protein p27by western blot respectively. miR-145 expression in healthy individuals was also compared with samples from advanced liver disease patients that include cirrhosis and HCC patients. Results: The expression of miR-145 was decreased significantly at 24, 48, 72 and 96 hours post-transfection in HBV transfected HepG2 cells compared to empty expression vector transfected HepG2 cells. Target mRNA and protein p27were up-regulated accordingly. Reduced expression of miR-145 was found in liver cirrhosis and HCC patients compared with healthy controls. Conclusion: The study revealed reduced expression of miR-145 and increased expression of MAP3K in liver cirrhosis and HCC patients and HCC derived cell lines. It expands our knowledge about complex host viral interactions leading to alteration of cellular genes and thus culminating into hepatic cancer." @default.
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- W2023971220 date "2014-03-01" @default.
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- W2023971220 title "miRNA-145 Expression is Reduced in HBV Infected Advanced Liver Patients and in Hepatoma Cells Infected with Full Length HBV Genome" @default.
- W2023971220 doi "https://doi.org/10.1016/j.jceh.2014.02.034" @default.
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