FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023971644> ?p ?o ?g. }

• W2023971644 endingPage "164" @default.
• W2023971644 startingPage "153" @default.
• W2023971644 abstract "Exposure of stage 9 quail (Coturnix coturnix japonica) embryos to glyceryl trinitrate (GTN) induces malformations that were associated in previous studies with an increase in protein nitration. Increased nitration suggests metabolism of GTN by the embryo. The goals of this study were to characterize the enzymes and co-factors required for GTN metabolism by quail embryos, and to determine the effects of in ovo treatment with N-acetyl cysteine (NAC), a precursor of glutathione (GSH), on GTN embryotoxicity. GTN treatment of quail embryos resulted in an increase in nitrite, a decrease in total GSH, and an increase in the ratio of NADP(+)/NADPH, indicating that redox balance may be compromised in exposed embryos. Glutathione S-transferases (GSTs; EC 2.5.1.18) purified from the whole embryo (K(m) 0.84 mM; V(max) 36 μM/min) and the embryonic eye (K(m) 0.20 mM; V(max) 30 μM/min) had GTN-metabolizing activity (1436 and 34 nmol/min/mg, respectively); the addition of ethacrynic acid, an inhibitor of GST activity, decreased GTN metabolism. Peptide sequencing of the GST isozymes indicated that alpha- or mu-type GSTs in the embryo and embryonic eye had GTN metabolizing activity. NAC co-treatment partially protected against the effects of GTN exposure. Thus, GTN denitration by quail embryo GSTs may represent a key initial step in the developmental toxicity of GTN." @default.
• W2023971644 created "2016-06-24" @default.
• W2023971644 creator A5015116970 @default.
• W2023971644 creator A5064334381 @default.
• W2023971644 creator A5070912142 @default.
• W2023971644 date "2013-07-01" @default.
• W2023971644 modified "2023-09-27" @default.
• W2023971644 title "Glyceryl trinitrate metabolism in the quail embryo by the glutathione S-transferases leads to a perturbation in redox status and embryotoxicity" @default.
• W2023971644 cites W1489691155 @default.
• W2023971644 cites W1564211517 @default.
• W2023971644 cites W1581414347 @default.
• W2023971644 cites W1802526536 @default.
• W2023971644 cites W1971056974 @default.
• W2023971644 cites W1978880986 @default.
• W2023971644 cites W1990250265 @default.
• W2023971644 cites W2002679487 @default.
• W2023971644 cites W2007064404 @default.
• W2023971644 cites W2010232053 @default.
• W2023971644 cites W2016139728 @default.
• W2023971644 cites W2017907872 @default.
• W2023971644 cites W2022026667 @default.
• W2023971644 cites W2022959333 @default.
• W2023971644 cites W2025301827 @default.
• W2023971644 cites W2026189634 @default.
• W2023971644 cites W2028767577 @default.
• W2023971644 cites W2031049356 @default.
• W2023971644 cites W2031935406 @default.
• W2023971644 cites W2034005931 @default.
• W2023971644 cites W2036477589 @default.
• W2023971644 cites W2045049518 @default.
• W2023971644 cites W2056938209 @default.
• W2023971644 cites W2062599245 @default.
• W2023971644 cites W2071563059 @default.
• W2023971644 cites W2078383532 @default.
• W2023971644 cites W2079051338 @default.
• W2023971644 cites W2080721489 @default.
• W2023971644 cites W2085644452 @default.
• W2023971644 cites W2086629541 @default.
• W2023971644 cites W2100837269 @default.
• W2023971644 cites W2101065625 @default.
• W2023971644 cites W2102948270 @default.
• W2023971644 cites W2106731905 @default.
• W2023971644 cites W2111640599 @default.
• W2023971644 cites W2115412169 @default.
• W2023971644 cites W2123632312 @default.
• W2023971644 cites W2130189571 @default.
• W2023971644 cites W2146393174 @default.
• W2023971644 cites W2150916538 @default.
• W2023971644 cites W2166337262 @default.
• W2023971644 cites W2167424396 @default.
• W2023971644 cites W2176976273 @default.
• W2023971644 cites W4238581030 @default.
• W2023971644 cites W4243696565 @default.
• W2023971644 cites W4254232721 @default.
• W2023971644 doi "https://doi.org/10.1016/j.cbpb.2013.04.001" @default.
• W2023971644 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23587908" @default.
• W2023971644 hasPublicationYear "2013" @default.
• W2023971644 type Work @default.
• W2023971644 sameAs 2023971644 @default.
• W2023971644 citedByCount "0" @default.
• W2023971644 crossrefType "journal-article" @default.
• W2023971644 hasAuthorship W2023971644A5015116970 @default.
• W2023971644 hasAuthorship W2023971644A5064334381 @default.
• W2023971644 hasAuthorship W2023971644A5070912142 @default.
• W2023971644 hasBestOaLocation W20239716442 @default.
• W2023971644 hasConcept C134018914 @default.
• W2023971644 hasConcept C181199279 @default.
• W2023971644 hasConcept C185592680 @default.
• W2023971644 hasConcept C196843134 @default.
• W2023971644 hasConcept C2777882087 @default.
• W2023971644 hasConcept C538909803 @default.
• W2023971644 hasConcept C54355233 @default.
• W2023971644 hasConcept C55493867 @default.
• W2023971644 hasConcept C62231903 @default.
• W2023971644 hasConcept C86803240 @default.
• W2023971644 hasConceptScore W2023971644C134018914 @default.
• W2023971644 hasConceptScore W2023971644C181199279 @default.
• W2023971644 hasConceptScore W2023971644C185592680 @default.
• W2023971644 hasConceptScore W2023971644C196843134 @default.
• W2023971644 hasConceptScore W2023971644C2777882087 @default.
• W2023971644 hasConceptScore W2023971644C538909803 @default.
• W2023971644 hasConceptScore W2023971644C54355233 @default.
• W2023971644 hasConceptScore W2023971644C55493867 @default.
• W2023971644 hasConceptScore W2023971644C62231903 @default.
• W2023971644 hasConceptScore W2023971644C86803240 @default.
• W2023971644 hasIssue "3" @default.
• W2023971644 hasLocation W20239716441 @default.
• W2023971644 hasLocation W20239716442 @default.
• W2023971644 hasLocation W20239716443 @default.
• W2023971644 hasOpenAccess W2023971644 @default.
• W2023971644 hasPrimaryLocation W20239716441 @default.
• W2023971644 hasRelatedWork W1992943993 @default.
• W2023971644 hasRelatedWork W1996878910 @default.
• W2023971644 hasRelatedWork W2030578844 @default.
• W2023971644 hasRelatedWork W2087077130 @default.
• W2023971644 hasRelatedWork W2363791668 @default.
• W2023971644 hasRelatedWork W2365957064 @default.
• W2023971644 hasRelatedWork W2382761319 @default.

• next