Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023971846> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2023971846 abstract "This study was designed to determine the role of cholecystokinin (CCK) in the inhibition of gastric HCl secretion by duodenal peptone, fat and acid in dogs with chronic gastric and pancreatic fistulas. Intraduodenal instillation of 5% peptone stimulated both gastric HCl secretion and pancreatic protein secretion and caused significant increments in plasma gastrin and CCK levels. L-364,718, a selective antagonist of CCK-A receptors, caused further increase in gastric HCl and plasma gastrin responses to duodenal peptone but reduced the pancreatic protein outputs in these tests by about 75%. L-365,260, an antagonist of type B receptors, reduced gastric acid by about 25% but failed to influence pancreatic response to duodenal peptone. Addition of 10% oleate or acidification of peptone to pH 3.0 profoundly inhibited acid secretion while significantly increasing the pancreatic protein secretion and plasma CCK levels. Administration of L-364,718 reversed the fall in gastric HCl secretion and significantly attenuated pancreatic protein secretion in tests with both peptone plus oleate and peptone plus acid. Exogenous CCK infused i.v. in a dose (25 pmol/kg per h) that raised plasma CCK to the level similar to that achieved by peptone meal plus fat resulted in similar inhibition of gastric acid response to that attained with fat and this effect was completely abolished by the pretreatment with L-364,718. We conclude that CCK released by intestinal peptone meal, containing fat or acid, exerts a tonic inhibitory influence on gastric acid secretion and gastrin release through the CCK-A receptors." @default.
- W2023971846 created "2016-06-24" @default.
- W2023971846 creator A5010769989 @default.
- W2023971846 creator A5087690868 @default.
- W2023971846 creator A5088820839 @default.
- W2023971846 date "1992-11-01" @default.
- W2023971846 modified "2023-10-12" @default.
- W2023971846 title "Role of cholecystokinin in the intestinal fat- and acid-induced inhibition of gastric secretion" @default.
- W2023971846 cites W1496422014 @default.
- W2023971846 cites W1506757151 @default.
- W2023971846 cites W1547247198 @default.
- W2023971846 cites W1789989039 @default.
- W2023971846 cites W1827454419 @default.
- W2023971846 cites W1948096088 @default.
- W2023971846 cites W1986832734 @default.
- W2023971846 cites W2020679272 @default.
- W2023971846 cites W2030975744 @default.
- W2023971846 cites W2093649467 @default.
- W2023971846 cites W2094542138 @default.
- W2023971846 cites W2144953427 @default.
- W2023971846 cites W2163470547 @default.
- W2023971846 cites W2182106707 @default.
- W2023971846 cites W2191986633 @default.
- W2023971846 cites W2422046106 @default.
- W2023971846 cites W2433856813 @default.
- W2023971846 cites W2461738421 @default.
- W2023971846 cites W66150762 @default.
- W2023971846 doi "https://doi.org/10.1016/0167-0115(92)90027-r" @default.
- W2023971846 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1475410" @default.
- W2023971846 hasPublicationYear "1992" @default.
- W2023971846 type Work @default.
- W2023971846 sameAs 2023971846 @default.
- W2023971846 citedByCount "17" @default.
- W2023971846 countsByYear W20239718462013 @default.
- W2023971846 countsByYear W20239718462017 @default.
- W2023971846 crossrefType "journal-article" @default.
- W2023971846 hasAuthorship W2023971846A5010769989 @default.
- W2023971846 hasAuthorship W2023971846A5087690868 @default.
- W2023971846 hasAuthorship W2023971846A5088820839 @default.
- W2023971846 hasConcept C126322002 @default.
- W2023971846 hasConcept C134018914 @default.
- W2023971846 hasConcept C170493617 @default.
- W2023971846 hasConcept C185592680 @default.
- W2023971846 hasConcept C2776885963 @default.
- W2023971846 hasConcept C2776986829 @default.
- W2023971846 hasConcept C2777504413 @default.
- W2023971846 hasConcept C2777593968 @default.
- W2023971846 hasConcept C2777951760 @default.
- W2023971846 hasConcept C2778395965 @default.
- W2023971846 hasConcept C32110497 @default.
- W2023971846 hasConcept C49039625 @default.
- W2023971846 hasConcept C56191518 @default.
- W2023971846 hasConcept C71924100 @default.
- W2023971846 hasConcept C86803240 @default.
- W2023971846 hasConceptScore W2023971846C126322002 @default.
- W2023971846 hasConceptScore W2023971846C134018914 @default.
- W2023971846 hasConceptScore W2023971846C170493617 @default.
- W2023971846 hasConceptScore W2023971846C185592680 @default.
- W2023971846 hasConceptScore W2023971846C2776885963 @default.
- W2023971846 hasConceptScore W2023971846C2776986829 @default.
- W2023971846 hasConceptScore W2023971846C2777504413 @default.
- W2023971846 hasConceptScore W2023971846C2777593968 @default.
- W2023971846 hasConceptScore W2023971846C2777951760 @default.
- W2023971846 hasConceptScore W2023971846C2778395965 @default.
- W2023971846 hasConceptScore W2023971846C32110497 @default.
- W2023971846 hasConceptScore W2023971846C49039625 @default.
- W2023971846 hasConceptScore W2023971846C56191518 @default.
- W2023971846 hasConceptScore W2023971846C71924100 @default.
- W2023971846 hasConceptScore W2023971846C86803240 @default.
- W2023971846 hasLocation W20239718461 @default.
- W2023971846 hasLocation W20239718462 @default.
- W2023971846 hasOpenAccess W2023971846 @default.
- W2023971846 hasPrimaryLocation W20239718461 @default.
- W2023971846 hasRelatedWork W1982594208 @default.
- W2023971846 hasRelatedWork W1993973335 @default.
- W2023971846 hasRelatedWork W2015597507 @default.
- W2023971846 hasRelatedWork W2023971846 @default.
- W2023971846 hasRelatedWork W2031272904 @default.
- W2023971846 hasRelatedWork W2069633620 @default.
- W2023971846 hasRelatedWork W2103989861 @default.
- W2023971846 hasRelatedWork W2107040575 @default.
- W2023971846 hasRelatedWork W2157742610 @default.
- W2023971846 hasRelatedWork W3099094780 @default.
- W2023971846 isParatext "false" @default.
- W2023971846 isRetracted "false" @default.
- W2023971846 magId "2023971846" @default.
- W2023971846 workType "article" @default.