FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023973572> ?p ?o ?g. }

• W2023973572 endingPage "1015" @default.
• W2023973572 startingPage "1004" @default.
• W2023973572 abstract "The misfolding and aggregation of amyloid-β (Aβ) peptides into amyloid fibrils is regarded as one of the causative events in the pathogenesis of Alzheimer's disease (AD). Tanshinones extracted from Chinese herb Danshen (Salvia Miltiorrhiza Bunge) were traditionally used as anti-inflammation and cerebrovascular drugs due to their antioxidation and antiacetylcholinesterase effects. A number of studies have suggested that tanshinones could protect neuronal cells. In this work, we examine the inhibitory activity of tanshinone I (TS1) and tanshinone IIA (TS2), the two major components in the Danshen herb, on the aggregation and toxicity of Aβ1-42 using atomic force microscopy (AFM), thioflavin-T (ThT) fluorescence assay, cell viability assay, and molecular dynamics (MD) simulations. AFM and ThT results show that both TS1 and TS2 exhibit different inhibitory abilities to prevent unseeded amyloid fibril formation and to disaggregate preformed amyloid fibrils, in which TS1 shows better inhibitory potency than TS2. Live/dead assay further confirms that introduction of a very small amount of tanshinones enables protection of cultured SH-SY5Y cells against Aβ-induced cell toxicity. Comparative MD simulation results reveal a general tanshinone binding mode to prevent Aβ peptide association, showing that both TS1 and TS2 preferentially bind to a hydrophobic β-sheet groove formed by the C-terminal residues of I31-M35 and M35-V39 and several aromatic residues. Meanwhile, the differences in binding distribution, residues, sites, population, and affinity between TS1-Aβ and TS2-Aβ systems also interpret different inhibitory effects on Aβ aggregation as observed by in vitro experiments. More importantly, due to nonspecific binding mode of tanshinones, it is expected that tanshinones would have a general inhibitory efficacy of a wide range of amyloid peptides. These findings suggest that tanshinones, particularly TS1 compound, offer promising lead compounds with dual protective role in anti-inflammation and antiaggregation for further development of Aβ inhibitors to prevent and disaggregate amyloid formation." @default.
• W2023973572 created "2016-06-24" @default.
• W2023973572 creator A5001285938 @default.
• W2023973572 creator A5005303316 @default.
• W2023973572 creator A5023540496 @default.
• W2023973572 creator A5024000881 @default.
• W2023973572 creator A5046575925 @default.
• W2023973572 creator A5050721982 @default.
• W2023973572 creator A5057875383 @default.
• W2023973572 date "2013-03-29" @default.
• W2023973572 modified "2023-09-29" @default.
• W2023973572 title "Tanshinones Inhibit Amyloid Aggregation by Amyloid-β Peptide, Disaggregate Amyloid Fibrils, and Protect Cultured Cells" @default.
• W2023973572 cites W1494074009 @default.
• W2023973572 cites W1529534608 @default.
• W2023973572 cites W1571193377 @default.
• W2023973572 cites W1589031564 @default.
• W2023973572 cites W1677883125 @default.
• W2023973572 cites W1710260509 @default.
• W2023973572 cites W1963591142 @default.
• W2023973572 cites W1967838681 @default.
• W2023973572 cites W1968990406 @default.
• W2023973572 cites W1971800836 @default.
• W2023973572 cites W1974448471 @default.
• W2023973572 cites W1976484299 @default.
• W2023973572 cites W1984720732 @default.
• W2023973572 cites W1996736279 @default.
• W2023973572 cites W1997021011 @default.
• W2023973572 cites W2004006602 @default.
• W2023973572 cites W2004400100 @default.
• W2023973572 cites W2007236469 @default.
• W2023973572 cites W2007402031 @default.
• W2023973572 cites W2008648606 @default.
• W2023973572 cites W2019441896 @default.
• W2023973572 cites W2020970511 @default.
• W2023973572 cites W2022864822 @default.
• W2023973572 cites W2027408247 @default.
• W2023973572 cites W2030934338 @default.
• W2023973572 cites W2032407364 @default.
• W2023973572 cites W2041134442 @default.
• W2023973572 cites W2043642345 @default.
• W2023973572 cites W2044597283 @default.
• W2023973572 cites W2047101142 @default.
• W2023973572 cites W2050210746 @default.
• W2023973572 cites W2051419785 @default.
• W2023973572 cites W2057226832 @default.
• W2023973572 cites W2062071602 @default.
• W2023973572 cites W2067484324 @default.
• W2023973572 cites W2072327749 @default.
• W2023973572 cites W2075582258 @default.
• W2023973572 cites W2086424384 @default.
• W2023973572 cites W2087748229 @default.
• W2023973572 cites W2088133972 @default.
• W2023973572 cites W2089727952 @default.
• W2023973572 cites W2091086263 @default.
• W2023973572 cites W2092887599 @default.
• W2023973572 cites W2094186244 @default.
• W2023973572 cites W2096192271 @default.
• W2023973572 cites W2096410114 @default.
• W2023973572 cites W2099370040 @default.
• W2023973572 cites W2103207165 @default.
• W2023973572 cites W2103815459 @default.
• W2023973572 cites W2105815637 @default.
• W2023973572 cites W2110793726 @default.
• W2023973572 cites W2117667119 @default.
• W2023973572 cites W2117938944 @default.
• W2023973572 cites W2118280241 @default.
• W2023973572 cites W2122320288 @default.
• W2023973572 cites W2122582863 @default.
• W2023973572 cites W2124929769 @default.
• W2023973572 cites W2133035474 @default.
• W2023973572 cites W2134347246 @default.
• W2023973572 cites W2136163423 @default.
• W2023973572 cites W2148139858 @default.
• W2023973572 cites W2154066769 @default.
• W2023973572 cites W2166190058 @default.
• W2023973572 cites W2169152986 @default.
• W2023973572 cites W2322219283 @default.
• W2023973572 doi "https://doi.org/10.1021/cn400051e" @default.
• W2023973572 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3756451" @default.
• W2023973572 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23506133" @default.
• W2023973572 hasPublicationYear "2013" @default.
• W2023973572 type Work @default.
• W2023973572 sameAs 2023973572 @default.
• W2023973572 citedByCount "166" @default.
• W2023973572 countsByYear W20239735722013 @default.
• W2023973572 countsByYear W20239735722014 @default.
• W2023973572 countsByYear W20239735722015 @default.
• W2023973572 countsByYear W20239735722016 @default.
• W2023973572 countsByYear W20239735722017 @default.
• W2023973572 countsByYear W20239735722018 @default.
• W2023973572 countsByYear W20239735722019 @default.
• W2023973572 countsByYear W20239735722020 @default.
• W2023973572 countsByYear W20239735722021 @default.
• W2023973572 countsByYear W20239735722022 @default.
• W2023973572 countsByYear W20239735722023 @default.
• W2023973572 crossrefType "journal-article" @default.
• W2023973572 hasAuthorship W2023973572A5001285938 @default.
• W2023973572 hasAuthorship W2023973572A5005303316 @default.

• next