FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023974718> ?p ?o ?g. }

• W2023974718 abstract "1. In pieces of guinea-pig liver with an intact capsule, the mean resting potential (E) is -49.8 mV, close to the value for in vivo hepatocytes and significantly higher than a similar preparation of rat liver. E is considerably less than the calculated K equilibrium potential of about -90 mV.2. Changes in [K(+)](o) in the range of 0-10 mM produce almost no change in E. At [K(+)](o) above 20 mM, a tenfold increase produces only a 33 mV depolarization. The results with changing [K(+)](o) are the same in Cl(-) free solutions (isethionate substitution) or when the [K(+)](o)[Cl(-)](o) product is kept constant. E rapidly returned to normal in liver pieces returned to Ringer after prolonged soaking in high K(+) solution.3. Changes in [Na(+)](o), [Cl(-)](o), [H(+)](o), [Ca(2+)](o) or [Mg(2+)](o) have little effect on E. Simultaneous variation of [Na(+)](o) and [Cl(-)](o) in opposite directions to maximize predicted changes in E also has only a minimal effect on E.4. Cyanide (5 mM) or ouabain (10(-4)M) cause depolarization, so there is no reason to believe that pumps sensitive to these poisons are normally lowering resting potential. Part of the normal E may be produced by an electrogenic ouabain-sensitive ion pump.5. The data is interpreted by using a form of the constant field equation developed by Brading & Caldwell (1971). Application of this method yields P(Na)/P(K) less than 0.04, P(Cl)/P(K) approximately 0.3. Additional terms, x and y, are required to account for the behaviour of E. Their physical basis remains undetermined.6. Suggestions are presented for further study and for the application of the method of Brading & Caldwell to other non-excitable cells and to excitable cells in low [K(+)](o), in which E is poorly understood." @default.
• W2023974718 created "2016-06-24" @default.
• W2023974718 creator A5031380490 @default.
• W2023974718 creator A5058968210 @default.
• W2023974718 date "1974-12-01" @default.
• W2023974718 modified "2023-09-25" @default.
• W2023974718 title "Transmembrane potentials in guinea-pig hepatocytes" @default.
• W2023974718 cites W1513783114 @default.
• W2023974718 cites W1519779876 @default.
• W2023974718 cites W1967028067 @default.
• W2023974718 cites W1967495220 @default.
• W2023974718 cites W1968404671 @default.
• W2023974718 cites W1969585426 @default.
• W2023974718 cites W1969687005 @default.
• W2023974718 cites W1969798959 @default.
• W2023974718 cites W1972371887 @default.
• W2023974718 cites W1973328199 @default.
• W2023974718 cites W1973679020 @default.
• W2023974718 cites W1979924760 @default.
• W2023974718 cites W1980971896 @default.
• W2023974718 cites W1985361107 @default.
• W2023974718 cites W1985473108 @default.
• W2023974718 cites W1985833687 @default.
• W2023974718 cites W1988351825 @default.
• W2023974718 cites W1990773110 @default.
• W2023974718 cites W1991217685 @default.
• W2023974718 cites W2000873394 @default.
• W2023974718 cites W2003409591 @default.
• W2023974718 cites W2003759451 @default.
• W2023974718 cites W2005321089 @default.
• W2023974718 cites W2006373684 @default.
• W2023974718 cites W2010680641 @default.
• W2023974718 cites W2015316024 @default.
• W2023974718 cites W2021839004 @default.
• W2023974718 cites W2022765359 @default.
• W2023974718 cites W2023636777 @default.
• W2023974718 cites W2025214823 @default.
• W2023974718 cites W2039861940 @default.
• W2023974718 cites W2049336896 @default.
• W2023974718 cites W2049525138 @default.
• W2023974718 cites W2052301886 @default.
• W2023974718 cites W2054596518 @default.
• W2023974718 cites W2055912261 @default.
• W2023974718 cites W2058952916 @default.
• W2023974718 cites W2062935768 @default.
• W2023974718 cites W2067312729 @default.
• W2023974718 cites W2072210797 @default.
• W2023974718 cites W2073826374 @default.
• W2023974718 cites W2074299829 @default.
• W2023974718 cites W2079201120 @default.
• W2023974718 cites W2080815444 @default.
• W2023974718 cites W2085895665 @default.
• W2023974718 cites W2087321060 @default.
• W2023974718 cites W2090277570 @default.
• W2023974718 cites W2111302981 @default.
• W2023974718 cites W2112387744 @default.
• W2023974718 cites W2113900828 @default.
• W2023974718 cites W2119579164 @default.
• W2023974718 cites W2125968048 @default.
• W2023974718 cites W2130506539 @default.
• W2023974718 cites W2133521914 @default.
• W2023974718 cites W2137166049 @default.
• W2023974718 cites W2147142035 @default.
• W2023974718 cites W2157389376 @default.
• W2023974718 cites W2158561731 @default.
• W2023974718 cites W2158601668 @default.
• W2023974718 cites W2199509437 @default.
• W2023974718 cites W2228616890 @default.
• W2023974718 cites W2311237560 @default.
• W2023974718 cites W2338645065 @default.
• W2023974718 cites W2362212804 @default.
• W2023974718 cites W2399451814 @default.
• W2023974718 cites W2410688437 @default.
• W2023974718 cites W2412568901 @default.
• W2023974718 cites W2415694398 @default.
• W2023974718 cites W2425698167 @default.
• W2023974718 cites W2469070843 @default.
• W2023974718 cites W2984710788 @default.
• W2023974718 doi "https://doi.org/10.1113/jphysiol.1974.sp010767" @default.
• W2023974718 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1330725" @default.
• W2023974718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4449075" @default.
• W2023974718 hasPublicationYear "1974" @default.
• W2023974718 type Work @default.
• W2023974718 sameAs 2023974718 @default.
• W2023974718 citedByCount "18" @default.
• W2023974718 countsByYear W20239747182018 @default.
• W2023974718 crossrefType "journal-article" @default.
• W2023974718 hasAuthorship W2023974718A5031380490 @default.
• W2023974718 hasAuthorship W2023974718A5058968210 @default.
• W2023974718 hasBestOaLocation W20239747182 @default.
• W2023974718 hasConcept C12554922 @default.
• W2023974718 hasConcept C134018914 @default.
• W2023974718 hasConcept C178790620 @default.
• W2023974718 hasConcept C181911157 @default.
• W2023974718 hasConcept C185592680 @default.
• W2023974718 hasConcept C2778815084 @default.
• W2023974718 hasConcept C2779133857 @default.
• W2023974718 hasConcept C4141045 @default.
• W2023974718 hasConcept C537181965 @default.
• W2023974718 hasConcept C55493867 @default.

• next