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• W2023981415 abstract "Social isolation has dramatic long-term physiological and psychological consequences; however, the mechanisms by which social isolation influences disease outcome are largely unknown. The purpose of the present study was to investigate the effects of social isolation on neuronal damage, neuroinflammation, and functional outcome after focal cerebral ischemia. Male mice were socially isolated (housed individually) or pair housed with an ovariectomized female before induction of stroke, via transient intraluminal middle cerebral artery occlusion (MCAO), or SHAM surgery. In these experiments, peri-ischemic social isolation decreases poststroke survival rate and exacerbates infarct size and edema development. The social influence on ischemic damage is accompanied by an altered neuroinflammatory response; specifically, central interleukin-6 (IL-6) signaling is down-regulated, whereas peripheral IL-6 is up-regulated, in isolated relative to socially housed mice. In addition, intracerebroventricular injection of an IL-6 neutralizing antibody (10 ng) eliminates social housing differences in measures of ischemic outcome. Taken together, these data suggest that central IL-6 is an important mediator of social influences on stroke outcome." @default.
• W2023981415 created "2016-06-24" @default.
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• W2023981415 date "2009-04-07" @default.
• W2023981415 modified "2023-10-18" @default.
• W2023981415 title "Social isolation alters neuroinflammatory response to stroke" @default.
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• W2023981415 doi "https://doi.org/10.1073/pnas.0810737106" @default.
• W2023981415 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2667090" @default.
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• W2023981415 hasPublicationYear "2009" @default.
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