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• W2023981583 startingPage "e186" @default.
• W2023981583 abstract "Mycobacteriophage Bxb1 integrates its DNA at the attB site of the Mycobacterium smegmatis genome using the viral attP site and a phage-encoded integrase generating the recombinant junctions attL and attR. The Bxb1 integrase is a member of the serine recombinase family of site-specific recombination proteins and utilizes small (<50 base pair) substrates for recombination, promoting strand exchange without the necessity for complex higher order macromolecular architectures. To elucidate the regulatory mechanism for the integration and excision reactions, we have identified a Bxb1-encoded recombination directionality factor (RDF), the product of gene 47. Bxb1 gp47 is an unusual RDF in that it is relatively large (̃28 kDa), unrelated to all other RDFs, and presumably performs dual functions since it is well conserved in mycobacteriophages that utilize unrelated integration systems. Furthermore, unlike other RDFs, Bxb1 gp47 does not bind DNA and functions solely through direct interaction with integrase–DNA complexes. The nature and consequences of this interaction depend on the specific DNA substrate to which integrase is bound, generating electrophoretically stable tertiary complexes with either attB or attP that are unable to undergo integrative recombination, and weakly bound, electrophoretically unstable complexes with either attL or attR that gain full potential for excisive recombination." @default.
• W2023981583 created "2016-06-24" @default.
• W2023981583 creator A5029786126 @default.
• W2023981583 creator A5041606725 @default.
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• W2023981583 date "2006-05-30" @default.
• W2023981583 modified "2023-10-18" @default.
• W2023981583 title "Control of Phage Bxb1 Excision by a Novel Recombination Directionality Factor" @default.
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• W2023981583 doi "https://doi.org/10.1371/journal.pbio.0040186" @default.
• W2023981583 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1470463" @default.
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• W2023981583 hasPublicationYear "2006" @default.
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