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- W2023984737 endingPage "1318" @default.
- W2023984737 startingPage "1305" @default.
- W2023984737 abstract "Abstract Aims In the metastatic stage, malignant melanoma is resistant to systemic treatment and carries a poor prognosis. A critical, evidence‐based analysis of standard approaches based on an extended search of published literature and from different Internet sources is presented. Material and methods A critical, evidence‐based analysis of standard approaches and their variations to systemic therapy based on an extended search of published literature and from different Internet sources is presented. Few meta‐analyses are available. Therefore, assessment of therapies is mainly based on randomized multicentre studies or clinical studies achieving an evidence level grade 1 or 2. Results Monotherapy with DTIC (dacarbazine) is the standard. Based on overall survival data, polychemotherapies cannot be recommended. Combination of polychemotherapy with the cytokines interferon‐α and interleukin‐2 substantially augments chemotherapy induced response rates, but a meta‐analysis for survival does not support its therapeutic superiority. Biological therapies such as vaccinations have not yet delivered results on a higher evidence level. Thus, immunotherapies as well as chemo‐immunotherapies will have to be evaluated in further studies. Conclusions Although the therapeutic efficacy is very limited, dacarbazine cannot be rejected as standard therapy for disseminated melanoma, because no other therapeutic regimen exhibits a survival benefit over DTIC in an evidence‐based analysis. This lack of therapeutic progress over the past 40 years clearly calls for further clinical studies, and patients should be enrolled into clinical trials whenever possible." @default.
- W2023984737 created "2016-06-24" @default.
- W2023984737 creator A5002731519 @default.
- W2023984737 creator A5031113622 @default.
- W2023984737 creator A5046274963 @default.
- W2023984737 creator A5070142178 @default.
- W2023984737 creator A5080805252 @default.
- W2023984737 date "2007-10-23" @default.
- W2023984737 modified "2023-10-16" @default.
- W2023984737 title "Systemic therapy of disseminated malignant melanoma: an evidence-based overview of the state-of-the-art in daily routine" @default.
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