Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023985259> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023985259 endingPage "185" @default.
- W2023985259 startingPage "181" @default.
- W2023985259 abstract "Cadherins (CDHs) are important in maintenance of cell adhesion and polarity, alterations of which contribute to tumorigenesis. Alterations of E-cadherin, a prototype CDH, have been reported in many cancers. However, alterations of unconventional CDHs, including CDH10, CDH24 and DCHS2 are largely unknown in cancers. Aim of this study was to explore whether CDH10, CDH24 and DCHS2 genes are mutated in gastric (GC) and colorectal cancers (CRC). In a public database, we found that CDH10, CDH24 and DCHS2 genes had mononucleotide repeats in the coding sequences that might be mutation targets in the cancers with microsatellite instability (MSI). We analyzed the mutations in 89 GC and 131 CRC (high MSI (MSI-H) or stable MSI/low MSI (MSS/MSI-L)) by single-strand conformation polymorphism analysis and DNA sequencing. We found six DCHS2, one CDH10 and one CDH24 frameshift mutations in them. All of the mutations were detected in cancers with MSI-H and there was a statistical difference in the frameshift mutation frequencies between the cancers with MSI-H (8/105) and MSS/MSI-L (0/115). The DCHS2 frameshift mutations were found in 8.8 % and 4.2 % of GC and CRC with MSI-H respectively. Our results show that unconventional CDH10, CDH24 and DCHS2 genes harbored frameshift mutations. These mutations might inactivate the cell adhesion-related functions and could be a feature of GC and CRC with MSI-H." @default.
- W2023985259 created "2016-06-24" @default.
- W2023985259 creator A5005287431 @default.
- W2023985259 creator A5030743761 @default.
- W2023985259 creator A5031578617 @default.
- W2023985259 creator A5039498684 @default.
- W2023985259 date "2014-06-05" @default.
- W2023985259 modified "2023-10-01" @default.
- W2023985259 title "Frameshift Mutations of Cadherin Genes DCHS2, CDH10 and CDH24 Genes in Gastric and Colorectal Cancers with High Microsatellite Instability" @default.
- W2023985259 cites W1575878259 @default.
- W2023985259 cites W1789875395 @default.
- W2023985259 cites W1901437611 @default.
- W2023985259 cites W1994847090 @default.
- W2023985259 cites W2023810501 @default.
- W2023985259 cites W2026262319 @default.
- W2023985259 cites W2036649093 @default.
- W2023985259 cites W2036832250 @default.
- W2023985259 cites W2037363141 @default.
- W2023985259 cites W2043281296 @default.
- W2023985259 cites W2048567930 @default.
- W2023985259 cites W2058214637 @default.
- W2023985259 cites W2067471997 @default.
- W2023985259 cites W2072626324 @default.
- W2023985259 cites W2096172976 @default.
- W2023985259 cites W2105209624 @default.
- W2023985259 cites W2105265676 @default.
- W2023985259 cites W2131348295 @default.
- W2023985259 cites W2154589460 @default.
- W2023985259 cites W2262414037 @default.
- W2023985259 doi "https://doi.org/10.1007/s12253-014-9804-8" @default.
- W2023985259 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24898286" @default.
- W2023985259 hasPublicationYear "2014" @default.
- W2023985259 type Work @default.
- W2023985259 sameAs 2023985259 @default.
- W2023985259 citedByCount "30" @default.
- W2023985259 countsByYear W20239852592015 @default.
- W2023985259 countsByYear W20239852592016 @default.
- W2023985259 countsByYear W20239852592017 @default.
- W2023985259 countsByYear W20239852592018 @default.
- W2023985259 countsByYear W20239852592019 @default.
- W2023985259 countsByYear W20239852592020 @default.
- W2023985259 countsByYear W20239852592021 @default.
- W2023985259 countsByYear W20239852592022 @default.
- W2023985259 crossrefType "journal-article" @default.
- W2023985259 hasAuthorship W2023985259A5005287431 @default.
- W2023985259 hasAuthorship W2023985259A5030743761 @default.
- W2023985259 hasAuthorship W2023985259A5031578617 @default.
- W2023985259 hasAuthorship W2023985259A5039498684 @default.
- W2023985259 hasConcept C104317684 @default.
- W2023985259 hasConcept C134935766 @default.
- W2023985259 hasConcept C1491633281 @default.
- W2023985259 hasConcept C149402561 @default.
- W2023985259 hasConcept C153911025 @default.
- W2023985259 hasConcept C180754005 @default.
- W2023985259 hasConcept C2779767149 @default.
- W2023985259 hasConcept C29906990 @default.
- W2023985259 hasConcept C501734568 @default.
- W2023985259 hasConcept C502942594 @default.
- W2023985259 hasConcept C54355233 @default.
- W2023985259 hasConcept C555283112 @default.
- W2023985259 hasConcept C60748783 @default.
- W2023985259 hasConcept C61320498 @default.
- W2023985259 hasConcept C86803240 @default.
- W2023985259 hasConceptScore W2023985259C104317684 @default.
- W2023985259 hasConceptScore W2023985259C134935766 @default.
- W2023985259 hasConceptScore W2023985259C1491633281 @default.
- W2023985259 hasConceptScore W2023985259C149402561 @default.
- W2023985259 hasConceptScore W2023985259C153911025 @default.
- W2023985259 hasConceptScore W2023985259C180754005 @default.
- W2023985259 hasConceptScore W2023985259C2779767149 @default.
- W2023985259 hasConceptScore W2023985259C29906990 @default.
- W2023985259 hasConceptScore W2023985259C501734568 @default.
- W2023985259 hasConceptScore W2023985259C502942594 @default.
- W2023985259 hasConceptScore W2023985259C54355233 @default.
- W2023985259 hasConceptScore W2023985259C555283112 @default.
- W2023985259 hasConceptScore W2023985259C60748783 @default.
- W2023985259 hasConceptScore W2023985259C61320498 @default.
- W2023985259 hasConceptScore W2023985259C86803240 @default.
- W2023985259 hasIssue "1" @default.
- W2023985259 hasLocation W20239852591 @default.
- W2023985259 hasLocation W20239852592 @default.
- W2023985259 hasOpenAccess W2023985259 @default.
- W2023985259 hasPrimaryLocation W20239852591 @default.
- W2023985259 hasRelatedWork W1857696717 @default.
- W2023985259 hasRelatedWork W1864290935 @default.
- W2023985259 hasRelatedWork W1972363155 @default.
- W2023985259 hasRelatedWork W2009029946 @default.
- W2023985259 hasRelatedWork W2023985259 @default.
- W2023985259 hasRelatedWork W2094651761 @default.
- W2023985259 hasRelatedWork W2124775785 @default.
- W2023985259 hasRelatedWork W2380809558 @default.
- W2023985259 hasRelatedWork W2997710417 @default.
- W2023985259 hasRelatedWork W3089298929 @default.
- W2023985259 hasVolume "21" @default.
- W2023985259 isParatext "false" @default.
- W2023985259 isRetracted "false" @default.
- W2023985259 magId "2023985259" @default.
- W2023985259 workType "article" @default.