FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023985345> ?p ?o ?g. }

• W2023985345 endingPage "92" @default.
• W2023985345 startingPage "85" @default.
• W2023985345 abstract "Pimecrolimus is a new non-steroidal inhibitor of T cell and mast cell activation. In the present study, we compared the potency of pimecrolimus and cyclosporin A (CyA) to inhibit cytokine synthesis of alloantigen-primed T cells and the expression of CD134 (OX40), an inducible co-receptor molecule thought to be critical for the survival and expansion of inflammation-mediating T cells. To mimic the physiological situation of recurrent antigenic stimulation, we have used dendritic cells (DC) as stimulators of purified CD4+ T cells in the primary and secondary allogeneic mixed lymphocyte culture (allo-MLC). Pimecrolimus inhibited surface expression of OX40 and prevented the up-regulation of CD25 and CD54 with a 10-fold higher potency compared to CyA. Similarly, 50% inhibition of allo-DC-mediated T cell proliferation by pimecrolimus was obtained at 0.55 nm, compared to about 12 nm for CyA. Furthermore, pimecrolimus blocked the increase of OX40 on primed T cells restimulated on day 10 in secondary allo-MLC. Allo-DC-primed T cells showed a restricted cytokine profile characterized by the production of TNF-alpha, IFN-gamma and IL-2 but low to undetectable levels of IL-4 and IL-10. The synthesis of TNF-alpha and IFN-gamma and the up-regulation of OX40 on T cells after secondary allogeneic stimulation were almost entirely blocked by 10 nm pimecrolimus. Taken together, pimecrolimus inhibits T cell proliferation and Th1 cytokine synthesis and also prevents the up-regulation of the OX40 co-receptor on primed T cells indicating its potential in the therapy of chronic inflammation and autoimmunity." @default.
• W2023985345 created "2016-06-24" @default.
• W2023985345 creator A5016303838 @default.
• W2023985345 creator A5045503403 @default.
• W2023985345 creator A5072143262 @default.
• W2023985345 date "2002-09-19" @default.
• W2023985345 modified "2023-09-30" @default.
• W2023985345 title "Pimecrolimus inhibits up-regulation of OX40 and synthesis of inflammatory cytokines upon secondary T cell activation by allogeneic dendritic cells" @default.
• W2023985345 cites W1490870966 @default.
• W2023985345 cites W1532995361 @default.
• W2023985345 cites W1534735809 @default.
• W2023985345 cites W1567963426 @default.
• W2023985345 cites W1579153734 @default.
• W2023985345 cites W1592534679 @default.
• W2023985345 cites W1595951835 @default.
• W2023985345 cites W1666489731 @default.
• W2023985345 cites W1670851308 @default.
• W2023985345 cites W1791922236 @default.
• W2023985345 cites W1934551616 @default.
• W2023985345 cites W1976112919 @default.
• W2023985345 cites W1981239780 @default.
• W2023985345 cites W1994688157 @default.
• W2023985345 cites W2002507218 @default.
• W2023985345 cites W2011073412 @default.
• W2023985345 cites W2019902454 @default.
• W2023985345 cites W2055874359 @default.
• W2023985345 cites W2068209234 @default.
• W2023985345 cites W2073391461 @default.
• W2023985345 cites W2087843772 @default.
• W2023985345 cites W2097957459 @default.
• W2023985345 cites W2117716734 @default.
• W2023985345 cites W2118884692 @default.
• W2023985345 cites W2120503420 @default.
• W2023985345 cites W2143488332 @default.
• W2023985345 cites W2153268818 @default.
• W2023985345 cites W2166280560 @default.
• W2023985345 cites W2172960056 @default.
• W2023985345 cites W2204690181 @default.
• W2023985345 cites W2442401665 @default.
• W2023985345 cites W4255061500 @default.
• W2023985345 doi "https://doi.org/10.1046/j.1365-2249.2002.01962.x" @default.
• W2023985345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1906497" @default.
• W2023985345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12296857" @default.
• W2023985345 hasPublicationYear "2002" @default.
• W2023985345 type Work @default.
• W2023985345 sameAs 2023985345 @default.
• W2023985345 citedByCount "27" @default.
• W2023985345 countsByYear W20239853452013 @default.
• W2023985345 countsByYear W20239853452021 @default.
• W2023985345 crossrefType "journal-article" @default.
• W2023985345 hasAuthorship W2023985345A5016303838 @default.
• W2023985345 hasAuthorship W2023985345A5045503403 @default.
• W2023985345 hasAuthorship W2023985345A5072143262 @default.
• W2023985345 hasBestOaLocation W20239853451 @default.
• W2023985345 hasConcept C126322002 @default.
• W2023985345 hasConcept C128057223 @default.
• W2023985345 hasConcept C203014093 @default.
• W2023985345 hasConcept C2776028589 @default.
• W2023985345 hasConcept C2776090121 @default.
• W2023985345 hasConcept C2778690821 @default.
• W2023985345 hasConcept C2911091166 @default.
• W2023985345 hasConcept C71924100 @default.
• W2023985345 hasConcept C79484868 @default.
• W2023985345 hasConcept C86803240 @default.
• W2023985345 hasConcept C8891405 @default.
• W2023985345 hasConcept C95444343 @default.
• W2023985345 hasConceptScore W2023985345C126322002 @default.
• W2023985345 hasConceptScore W2023985345C128057223 @default.
• W2023985345 hasConceptScore W2023985345C203014093 @default.
• W2023985345 hasConceptScore W2023985345C2776028589 @default.
• W2023985345 hasConceptScore W2023985345C2776090121 @default.
• W2023985345 hasConceptScore W2023985345C2778690821 @default.
• W2023985345 hasConceptScore W2023985345C2911091166 @default.
• W2023985345 hasConceptScore W2023985345C71924100 @default.
• W2023985345 hasConceptScore W2023985345C79484868 @default.
• W2023985345 hasConceptScore W2023985345C86803240 @default.
• W2023985345 hasConceptScore W2023985345C8891405 @default.
• W2023985345 hasConceptScore W2023985345C95444343 @default.
• W2023985345 hasIssue "1" @default.
• W2023985345 hasLocation W20239853451 @default.
• W2023985345 hasLocation W20239853452 @default.
• W2023985345 hasLocation W20239853453 @default.
• W2023985345 hasOpenAccess W2023985345 @default.
• W2023985345 hasPrimaryLocation W20239853451 @default.
• W2023985345 hasRelatedWork W123703021 @default.
• W2023985345 hasRelatedWork W1963666650 @default.
• W2023985345 hasRelatedWork W1978951073 @default.
• W2023985345 hasRelatedWork W1987190665 @default.
• W2023985345 hasRelatedWork W2004989362 @default.
• W2023985345 hasRelatedWork W2023985345 @default.
• W2023985345 hasRelatedWork W2082440479 @default.
• W2023985345 hasRelatedWork W2138905083 @default.
• W2023985345 hasRelatedWork W3029694895 @default.
• W2023985345 hasRelatedWork W4367172882 @default.
• W2023985345 hasVolume "130" @default.
• W2023985345 isParatext "false" @default.
• W2023985345 isRetracted "false" @default.
• W2023985345 magId "2023985345" @default.

• next