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• W2023985368 endingPage "S6" @default.
• W2023985368 startingPage "S6" @default.
• W2023985368 abstract "To properly characterize protective polyclonal antibody responses, it is necessary to examine epitope specificity. Most antibody epitopes are conformational in nature and, thus, cannot be identified using synthetic linear peptides. Cyclic peptides can function as mimetics of conformational epitopes (termed mimotopes), thereby providing targets, which can be selected by immunoaffinity purification. However, the management of large collections of random cyclic peptides is cumbersome. Filamentous bacteriophage provides a useful scaffold for the expression of random peptides (termed phage display) facilitating both the production and manipulation of complex peptide libraries. Immunoaffinity selection of phage displaying random cyclic peptides is an effective strategy for isolating mimotopes with specificity for a given antiserum. Further epitope prediction based on mimotope sequence is not trivial since mimotopes generally display only small homologies with the target protein. Large numbers of unique mimotopes are required to provide sufficient sequence coverage to elucidate the target epitope. We have developed a method based on pattern recognition theory to deal with the complexity of large collections of conformational mimotopes. The analysis consists of two phases: 1) The learning phase where a large collection of epitope-specific mimotopes is analyzed to identify epitope specific “signs” and 2) The identification phase where immunoaffinity-selected mimotopes are interrogated for the presence of the epitope specific “signs” and assigned to specific epitopes. We are currently using computational methods to define epitope “signs” without the need for prior knowledge of specific mimotopes. This technology provides an important tool for characterizing the breadth of antibody specificities within polyclonal antisera." @default.
• W2023985368 created "2016-06-24" @default.
• W2023985368 creator A5001828917 @default.
• W2023985368 creator A5045671822 @default.
• W2023985368 creator A5076165905 @default.
• W2023985368 date "2010-01-01" @default.
• W2023985368 modified "2023-10-03" @default.
• W2023985368 title "Applying bioinformatics for antibody epitope prediction using affinity-selected mimotopes – relevance for vaccine design" @default.
• W2023985368 cites W1494163886 @default.
• W2023985368 cites W1559176388 @default.
• W2023985368 cites W1605208680 @default.
• W2023985368 cites W1913862483 @default.
• W2023985368 cites W1918095030 @default.
• W2023985368 cites W1922600462 @default.
• W2023985368 cites W1964871486 @default.
• W2023985368 cites W1967016540 @default.
• W2023985368 cites W1968643522 @default.
• W2023985368 cites W1968867687 @default.
• W2023985368 cites W1974658658 @default.
• W2023985368 cites W1975291301 @default.
• W2023985368 cites W1975392270 @default.
• W2023985368 cites W1979040187 @default.
• W2023985368 cites W1979673907 @default.
• W2023985368 cites W1981342084 @default.
• W2023985368 cites W1982490791 @default.
• W2023985368 cites W1994434787 @default.
• W2023985368 cites W1994501723 @default.
• W2023985368 cites W2004416935 @default.
• W2023985368 cites W2006315372 @default.
• W2023985368 cites W2006398943 @default.
• W2023985368 cites W2012465168 @default.
• W2023985368 cites W2015556511 @default.
• W2023985368 cites W2017880958 @default.
• W2023985368 cites W2018115736 @default.
• W2023985368 cites W2023338795 @default.
• W2023985368 cites W2023815018 @default.
• W2023985368 cites W2028493269 @default.
• W2023985368 cites W2029633855 @default.
• W2023985368 cites W2041485149 @default.
• W2023985368 cites W2042492527 @default.
• W2023985368 cites W2043373937 @default.
• W2023985368 cites W2045101022 @default.
• W2023985368 cites W2046180857 @default.
• W2023985368 cites W2055191187 @default.
• W2023985368 cites W2058860357 @default.
• W2023985368 cites W2060127667 @default.
• W2023985368 cites W2060928208 @default.
• W2023985368 cites W2064298344 @default.
• W2023985368 cites W2065236789 @default.
• W2023985368 cites W2069649999 @default.
• W2023985368 cites W2072698880 @default.
• W2023985368 cites W2072787364 @default.
• W2023985368 cites W2074492466 @default.
• W2023985368 cites W2075494795 @default.
• W2023985368 cites W2080423713 @default.
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• W2023985368 cites W2133054005 @default.
• W2023985368 cites W2135586616 @default.
• W2023985368 cites W2136206140 @default.
• W2023985368 cites W2137575262 @default.
• W2023985368 cites W2138551719 @default.
• W2023985368 cites W2148366966 @default.
• W2023985368 cites W2150632109 @default.
• W2023985368 cites W2150900888 @default.
• W2023985368 cites W2151598579 @default.
• W2023985368 cites W2155854270 @default.
• W2023985368 cites W2167934144 @default.
• W2023985368 cites W2287669208 @default.
• W2023985368 cites W2407087151 @default.
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• W2023985368 doi "https://doi.org/10.1186/1745-7580-6-s2-s6" @default.
• W2023985368 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2981875" @default.
• W2023985368 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21067548" @default.
• W2023985368 hasPublicationYear "2010" @default.
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