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- W2023989825 abstract "This paper describes the clinicopathologic events associated with a recently documented placental alteration. “Hemorrhagic endovasculitis” is occurring with considerable (20%) frequency in placentas referred to the Michigan Placental Tissue Registry. Slightly more than half of the associated infants are stillborn. Live-born infants are frequently in distress or small for gestational age. The alteration appears to focus on fetal placental blood vessels resulting in intimal proliferation, nonexudative necrosis of vessel walls, widespread thrombosis, destruction of the infant's RBCs and hemorrhage within the placenta. Many features simulate the placental and fetal response to some viral infections that occur in pregnancy. Chronic villitis is a frequent associated finding. Inclusion bodies have been observed in approximately six percent of cases; three were cytomegalovirus inclusions associated with known intrauterine cytomegalovirus infection. Placentas so affected have occurred in successive pregnancies in several patients who delivered infants who are stillborn, in distress or small for gestational age. Similarities to other infectious associated conditions including the hemolyticuremic syndrome, other microangiopathic hemolytic anemias, post-measles encephalitis and Reye's syndrome exist. Commonality in pathogenesis may involve an altered immunologic response resulting in selective tissue damage." @default.
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- W2023989825 date "1981-04-01" @default.
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- W2023989825 title "1063 HEMORRHAGIC ENDOVASCULITIS OF THE PLACENTA – A POSSIBLE FORM OF THROMBOTIC MICROANGIOPATHY" @default.
- W2023989825 doi "https://doi.org/10.1203/00006450-198104001-01089" @default.
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