FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023989911> ?p ?o ?g. }

• W2023989911 endingPage "166" @default.
• W2023989911 startingPage "153" @default.
• W2023989911 abstract "That enzyme fractions derived from animals chronically fed alcohol can alter the metabolism of carcinogenic xenobiotic compounds has been documented. To further understand this relationship the mutagenicity of 3 aromatic amines was determined in the Ames test, employing activation systems derived from rats maintained on an alcohol-containing liquid diet, an isocaloric control liquid diet or Aroclor 1254-pretreated animals fed standard laboratory chow. Depending upon protein and substrate concentrations, S9 from ethanol-fed rats was 30–50% less efficient than S9 from pair-fed rats in activating arylamines (2-aminofluorene, 2-aminoanthracene and 2-acetylaminofluorene) to mutagens in Salmonella typhimurium TA98 and TA100. Cytosolic fractions from ethanol-fed animals always resulted in greater arylamine activation than that of controls whereas the opposite was true of the microsomal compartment in which the ethanol-treated group was consistently less active than the controls. The cytosolic N-acetyltransferase activities with respect to 2 different substrates, isoniazid and 2-aminofluorence, were unaffected by ethanol consumption, indicating that this activity probably does not account for the different activation profiles exhibited by the ethanol and pair-fed cytosolic systems. Both the cytosolic and microsomal compartments are required for maximal expression of the mutagenicity of each arylamine however, each compartment can activate arylamines independently of the other. Reconstituting cytosol with microsomes from ethanol- and pair-fed rats, but not Aroclor-pretreated rats, resulted in a synergistic activation of the aromatic amines and displayed an effect similar to that of S9. Compared to Aroclor pretreatment and pair-fed controls, mitrosomes from ethanol-fed rats displayed the least capacity for activating any of the arylamines to mutagens. Microsomes from Aroclor-pretreated rats accounted for at least 80% of the S9-mediated activation of each of the arylamines to mutagenic metabolites which was in marked contrast to the contribution of the microsomal fractions to the S9 activity in the ethanol- (5–20% of S9 activity) and pair-fed systems (22–30% of S9 activity). The data indicate that 2 opposing reactions occur in S9, a cytosolic activity that augments and a microsomal activity that attenuates the mutagenicity of arylamines. Both activities are modified by ethanol consumption and Aroclor pretreatment." @default.
• W2023989911 created "2016-06-24" @default.
• W2023989911 creator A5023027523 @default.
• W2023989911 creator A5024316980 @default.
• W2023989911 creator A5046169750 @default.
• W2023989911 creator A5075186461 @default.
• W2023989911 date "1991-03-01" @default.
• W2023989911 modified "2023-09-27" @default.
• W2023989911 title "Arylamine activation following chronic ethanol ingestion by rats: studies on the liver S9, microsomal and cytosolic fractions and comparison with Aroclor 1254 pretreatment" @default.
• W2023989911 cites W1533807800 @default.
• W2023989911 cites W1568120202 @default.
• W2023989911 cites W1584235297 @default.
• W2023989911 cites W1775749144 @default.
• W2023989911 cites W1981804366 @default.
• W2023989911 cites W1983386629 @default.
• W2023989911 cites W1985256593 @default.
• W2023989911 cites W1988403667 @default.
• W2023989911 cites W1989640442 @default.
• W2023989911 cites W1991926100 @default.
• W2023989911 cites W1998240465 @default.
• W2023989911 cites W2003626253 @default.
• W2023989911 cites W2005156172 @default.
• W2023989911 cites W2020267550 @default.
• W2023989911 cites W2020446707 @default.
• W2023989911 cites W2033980786 @default.
• W2023989911 cites W2055546523 @default.
• W2023989911 cites W2055621624 @default.
• W2023989911 cites W2058349506 @default.
• W2023989911 cites W2077085708 @default.
• W2023989911 cites W2078808118 @default.
• W2023989911 cites W2083548377 @default.
• W2023989911 cites W2085296391 @default.
• W2023989911 cites W2090342006 @default.
• W2023989911 cites W2092685652 @default.
• W2023989911 cites W2116300323 @default.
• W2023989911 cites W2118092388 @default.
• W2023989911 cites W2118800463 @default.
• W2023989911 cites W2362717657 @default.
• W2023989911 cites W83527592 @default.
• W2023989911 cites W986959249 @default.
• W2023989911 doi "https://doi.org/10.1016/0027-5107(91)90043-n" @default.
• W2023989911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2002800" @default.
• W2023989911 hasPublicationYear "1991" @default.
• W2023989911 type Work @default.
• W2023989911 sameAs 2023989911 @default.
• W2023989911 citedByCount "11" @default.
• W2023989911 crossrefType "journal-article" @default.
• W2023989911 hasAuthorship W2023989911A5023027523 @default.
• W2023989911 hasAuthorship W2023989911A5024316980 @default.
• W2023989911 hasAuthorship W2023989911A5046169750 @default.
• W2023989911 hasAuthorship W2023989911A5075186461 @default.
• W2023989911 hasConcept C114246631 @default.
• W2023989911 hasConcept C178790620 @default.
• W2023989911 hasConcept C181199279 @default.
• W2023989911 hasConcept C185592680 @default.
• W2023989911 hasConcept C2780161600 @default.
• W2023989911 hasConcept C2781066024 @default.
• W2023989911 hasConcept C29730261 @default.
• W2023989911 hasConcept C55493867 @default.
• W2023989911 hasConcept C62231903 @default.
• W2023989911 hasConcept C86803240 @default.
• W2023989911 hasConcept C87644729 @default.
• W2023989911 hasConcept C98274493 @default.
• W2023989911 hasConcept C98539663 @default.
• W2023989911 hasConceptScore W2023989911C114246631 @default.
• W2023989911 hasConceptScore W2023989911C178790620 @default.
• W2023989911 hasConceptScore W2023989911C181199279 @default.
• W2023989911 hasConceptScore W2023989911C185592680 @default.
• W2023989911 hasConceptScore W2023989911C2780161600 @default.
• W2023989911 hasConceptScore W2023989911C2781066024 @default.
• W2023989911 hasConceptScore W2023989911C29730261 @default.
• W2023989911 hasConceptScore W2023989911C55493867 @default.
• W2023989911 hasConceptScore W2023989911C62231903 @default.
• W2023989911 hasConceptScore W2023989911C86803240 @default.
• W2023989911 hasConceptScore W2023989911C87644729 @default.
• W2023989911 hasConceptScore W2023989911C98274493 @default.
• W2023989911 hasConceptScore W2023989911C98539663 @default.
• W2023989911 hasIssue "1" @default.
• W2023989911 hasLocation W20239899111 @default.
• W2023989911 hasLocation W20239899112 @default.
• W2023989911 hasOpenAccess W2023989911 @default.
• W2023989911 hasPrimaryLocation W20239899111 @default.
• W2023989911 hasRelatedWork W1486163284 @default.
• W2023989911 hasRelatedWork W1504984673 @default.
• W2023989911 hasRelatedWork W1966299436 @default.
• W2023989911 hasRelatedWork W1972171507 @default.
• W2023989911 hasRelatedWork W1977200340 @default.
• W2023989911 hasRelatedWork W2027139073 @default.
• W2023989911 hasRelatedWork W2028489185 @default.
• W2023989911 hasRelatedWork W2052034756 @default.
• W2023989911 hasRelatedWork W2083302194 @default.
• W2023989911 hasRelatedWork W2328530460 @default.
• W2023989911 hasVolume "247" @default.
• W2023989911 isParatext "false" @default.
• W2023989911 isRetracted "false" @default.
• W2023989911 magId "2023989911" @default.
• W2023989911 workType "article" @default.