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• W2023990045 abstract "Werner Syndrome (WS) is a human segmental progeria resulting from mutations in a DNA helicase. WS fibroblasts have a shortened replicative capacity, an aged appearance, and activated p38 MAPK, features that can be modulated by inhibition of the p38 pathway. Loss of the WRNp RecQ helicase has been shown to result in replicative stress, suggesting that a link between faulty DNA repair and stress-induced premature cellular senescence may lead to premature ageing in WS. Other progeroid syndromes that share overlapping pathophysiological features with WS also show defects in DNA processing, raising the possibility that faulty DNA repair, leading to replicative stress and premature cellular senescence, might be a more widespread feature of premature ageing syndromes. We therefore analysed replicative capacity, cellular morphology and p38 activation, and the effects of p38 inhibition, in fibroblasts from a range of progeroid syndromes. In general, populations of young fibroblasts from non-WS progeroid syndromes do not have a high level of cells with an enlarged morphology and F-actin stress fibres, unlike young WS cells, although this varies between strains. p38 activation and phosphorylated HSP27 levels generally correlate well with cellular morphology, and treatment with the p38 inhibitor SB203580 effects cellular morphology only in strains with enlarged cells and phosphorylated HSP27. For some syndromes fibroblast replicative capacity was within the normal range, whereas for others it was significantly shorter (e.g. HGPS and DKC). However, although in most cases SB203580 extended replicative capacity, with the exception of WS and DKC the magnitude of the effect was not significantly different from normal dermal fibroblasts. This suggests that stress-induced premature cellular senescence via p38 activation is restricted to a small subset of progeroid syndromes." @default.
• W2023990045 created "2016-06-24" @default.
• W2023990045 creator A5002268030 @default.
• W2023990045 creator A5039046283 @default.
• W2023990045 creator A5044268272 @default.
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• W2023990045 creator A5064980110 @default.
• W2023990045 date "2012-10-31" @default.
• W2023990045 modified "2023-10-15" @default.
• W2023990045 title "p38 MAPK stress signalling in replicative senescence in fibroblasts from progeroid and genomic instability syndromes" @default.
• W2023990045 cites W1487697828 @default.
• W2023990045 cites W1555218304 @default.
• W2023990045 cites W1968460725 @default.
• W2023990045 cites W1968958521 @default.
• W2023990045 cites W1970829117 @default.
• W2023990045 cites W1970891016 @default.
• W2023990045 cites W1975386903 @default.
• W2023990045 cites W1975509421 @default.
• W2023990045 cites W1976273464 @default.
• W2023990045 cites W1983673827 @default.
• W2023990045 cites W1984190007 @default.
• W2023990045 cites W1986594019 @default.
• W2023990045 cites W1989335335 @default.
• W2023990045 cites W1992520556 @default.
• W2023990045 cites W1993922963 @default.
• W2023990045 cites W1998663807 @default.
• W2023990045 cites W2001884031 @default.
• W2023990045 cites W2001927863 @default.
• W2023990045 cites W2002334953 @default.
• W2023990045 cites W2008743975 @default.
• W2023990045 cites W2011482325 @default.
• W2023990045 cites W2013798852 @default.
• W2023990045 cites W2018030875 @default.
• W2023990045 cites W2022746129 @default.
• W2023990045 cites W2023312698 @default.
• W2023990045 cites W2031797863 @default.
• W2023990045 cites W2032874501 @default.
• W2023990045 cites W2035963497 @default.
• W2023990045 cites W2036066169 @default.
• W2023990045 cites W2037435562 @default.
• W2023990045 cites W2037703099 @default.
• W2023990045 cites W2040448220 @default.
• W2023990045 cites W2042000503 @default.
• W2023990045 cites W2045814034 @default.
• W2023990045 cites W2062395030 @default.
• W2023990045 cites W2066173542 @default.
• W2023990045 cites W2067933702 @default.
• W2023990045 cites W2070775649 @default.
• W2023990045 cites W2072428636 @default.
• W2023990045 cites W2077772514 @default.
• W2023990045 cites W2083140157 @default.
• W2023990045 cites W2083809000 @default.
• W2023990045 cites W2086598375 @default.
• W2023990045 cites W2086877549 @default.
• W2023990045 cites W2088672106 @default.
• W2023990045 cites W2095000492 @default.
• W2023990045 cites W2097246782 @default.
• W2023990045 cites W2104908670 @default.
• W2023990045 cites W2105144878 @default.
• W2023990045 cites W2108482850 @default.
• W2023990045 cites W2114342948 @default.
• W2023990045 cites W2117331734 @default.
• W2023990045 cites W2117824620 @default.
• W2023990045 cites W2122578071 @default.
• W2023990045 cites W2128205759 @default.
• W2023990045 cites W2128668256 @default.
• W2023990045 cites W2129809714 @default.
• W2023990045 cites W2145619597 @default.
• W2023990045 cites W2147992602 @default.
• W2023990045 cites W2148221837 @default.
• W2023990045 cites W2158245724 @default.
• W2023990045 cites W2160848134 @default.
• W2023990045 cites W2161183147 @default.
• W2023990045 cites W2163819508 @default.
• W2023990045 cites W2167545422 @default.
• W2023990045 cites W2168395104 @default.
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• W2023990045 doi "https://doi.org/10.1007/s10522-012-9407-2" @default.
• W2023990045 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3627027" @default.
• W2023990045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23112078" @default.
• W2023990045 hasPublicationYear "2012" @default.
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