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- W2023991830 abstract "Cell migration involves a multitude of signals that converge on cytoskeletal reorganization, essential for development, immune responses and tissue repair. Using knockdown and dominant negative approaches, we show that the microtubule-associated Ste20-like kinase SLK is required for focal adhesion turnover and cell migration downstream of the FAK/c-src complex. Our results show that SLK co-localizes with paxillin, Rac1 and the microtubules at the leading edge of migrating cells and is activated by scratch wounding. SLK activation is dependent on FAK/c-src/MAPK signaling, whereas SLK recruitment to the leading edge is src-dependent but FAK independent. Our results show that SLK represents a novel focal adhesion disassembly signal." @default.
- W2023991830 created "2016-06-24" @default.
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- W2023991830 date "2008-04-02" @default.
- W2023991830 modified "2023-09-24" @default.
- W2023991830 title "FAK/src-Family Dependent Activation of the Ste20-Like Kinase SLK Is Required for Microtubule-Dependent Focal Adhesion Turnover and Cell Migration" @default.
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- W2023991830 doi "https://doi.org/10.1371/journal.pone.0001868" @default.
- W2023991830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2270904" @default.
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