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- W2023992238 abstract "Abstract Male mice bearing Harding-Passey melanomas were given ip injections of the investigated drugs once daily, for 7 days. On the fifth day of treatment, 1 μCi of DOPA- 14 C (3.93 mCi/m m ) was administered ip. The mice were decapitated 72 hours after the injection, and the tumors were excised and homogenized. The radioactivity in the melanosome-containing fraction (9000 g sediment) was measured by liquid scintillation procedures. Treatment with 5 mg/kg chlorpromazine or 0.5 mg/kg reserpine increased the specific activity of the melanosome-containing fraction. The specific activity of the melanosome-containing fractions from tumors in mice treated with 100 mg/kg phenobarbital, 25 mg/kg chlorpromazine sulfoxide, or 0.64 mg/kg yohimbine did not differ from control values. The rate of in vitro conversion of DOPA to melanin by tyrosinase present in the melanosome-containing fraction was not influenced by chlorpromazine pretreatment or by the addition of 10 −4 m chlorpromazine to the reaction mixture. Apparent kinetic constants for tyrosinase isolated from chlorpromazine-treated mice were identical with controls." @default.
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- W2023992238 date "1970-03-01" @default.
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- W2023992238 title "Stimulation of DOPA-14C incorporation into melanoma tissue by chlorpromazine and reserpine" @default.
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- W2023992238 doi "https://doi.org/10.1016/0041-008x(70)90015-3" @default.
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