Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023992918> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2023992918 endingPage "4405" @default.
- W2023992918 startingPage "4403" @default.
- W2023992918 abstract "Hypoxia-inducible factor (HIF)-1alpha undergoes degradation under normoxia, which involves its proline hydroxylation and subsequent binding of proline-hydroxylated HIF-1alpha to the von Hippel-Lindau protein-Elongin B-Elongin C (VBC) complex. In this study, we designed and synthesized a series of peptides containing 556-575 residues of HIF-1alpha with modifications at the Pro-564 residue to inhibit the interaction between proline-hydroxylated HIF-1alpha and VBC. Employing a fluorescence polarization-based interaction assay, we evaluated inhibitory potency of these peptides and selected potent inhibitors. We then analyzed their effects in the cell level to show that the selected inhibitors induced HIF-1alpha stabilization in normoxic cells. Considering that proline hydroxylation of HIF-1alpha is routinely targeted for modulating the HIF pathway, our approach of using inhibitors against the interactions between HIF-1alpha and VBC would provide an alternative way of upregulating HIF-1 activity." @default.
- W2023992918 created "2016-06-24" @default.
- W2023992918 creator A5017116763 @default.
- W2023992918 creator A5029512205 @default.
- W2023992918 creator A5047364395 @default.
- W2023992918 creator A5048297833 @default.
- W2023992918 date "2009-08-01" @default.
- W2023992918 modified "2023-10-17" @default.
- W2023992918 title "HIF-1α peptide derivatives with modifications at the hydroxyproline residue as activators of HIF-1α" @default.
- W2023992918 cites W1970623201 @default.
- W2023992918 cites W1983127951 @default.
- W2023992918 cites W2000877907 @default.
- W2023992918 cites W2030634993 @default.
- W2023992918 cites W2040272329 @default.
- W2023992918 cites W2074061842 @default.
- W2023992918 cites W2105962920 @default.
- W2023992918 cites W2135178058 @default.
- W2023992918 cites W2596045242 @default.
- W2023992918 doi "https://doi.org/10.1016/j.bmcl.2009.05.083" @default.
- W2023992918 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19515556" @default.
- W2023992918 hasPublicationYear "2009" @default.
- W2023992918 type Work @default.
- W2023992918 sameAs 2023992918 @default.
- W2023992918 citedByCount "10" @default.
- W2023992918 countsByYear W20239929182012 @default.
- W2023992918 countsByYear W20239929182013 @default.
- W2023992918 countsByYear W20239929182015 @default.
- W2023992918 countsByYear W20239929182017 @default.
- W2023992918 countsByYear W20239929182020 @default.
- W2023992918 countsByYear W20239929182021 @default.
- W2023992918 countsByYear W20239929182022 @default.
- W2023992918 countsByYear W20239929182023 @default.
- W2023992918 crossrefType "journal-article" @default.
- W2023992918 hasAuthorship W2023992918A5017116763 @default.
- W2023992918 hasAuthorship W2023992918A5029512205 @default.
- W2023992918 hasAuthorship W2023992918A5047364395 @default.
- W2023992918 hasAuthorship W2023992918A5048297833 @default.
- W2023992918 hasConcept C104317684 @default.
- W2023992918 hasConcept C160450060 @default.
- W2023992918 hasConcept C181199279 @default.
- W2023992918 hasConcept C185592680 @default.
- W2023992918 hasConcept C202751555 @default.
- W2023992918 hasConcept C2779281246 @default.
- W2023992918 hasConcept C2779797417 @default.
- W2023992918 hasConcept C2779815552 @default.
- W2023992918 hasConcept C2781109383 @default.
- W2023992918 hasConcept C2781338088 @default.
- W2023992918 hasConcept C515207424 @default.
- W2023992918 hasConcept C55493867 @default.
- W2023992918 hasConcept C57992300 @default.
- W2023992918 hasConcept C71240020 @default.
- W2023992918 hasConceptScore W2023992918C104317684 @default.
- W2023992918 hasConceptScore W2023992918C160450060 @default.
- W2023992918 hasConceptScore W2023992918C181199279 @default.
- W2023992918 hasConceptScore W2023992918C185592680 @default.
- W2023992918 hasConceptScore W2023992918C202751555 @default.
- W2023992918 hasConceptScore W2023992918C2779281246 @default.
- W2023992918 hasConceptScore W2023992918C2779797417 @default.
- W2023992918 hasConceptScore W2023992918C2779815552 @default.
- W2023992918 hasConceptScore W2023992918C2781109383 @default.
- W2023992918 hasConceptScore W2023992918C2781338088 @default.
- W2023992918 hasConceptScore W2023992918C515207424 @default.
- W2023992918 hasConceptScore W2023992918C55493867 @default.
- W2023992918 hasConceptScore W2023992918C57992300 @default.
- W2023992918 hasConceptScore W2023992918C71240020 @default.
- W2023992918 hasIssue "15" @default.
- W2023992918 hasLocation W20239929181 @default.
- W2023992918 hasLocation W20239929182 @default.
- W2023992918 hasOpenAccess W2023992918 @default.
- W2023992918 hasPrimaryLocation W20239929181 @default.
- W2023992918 hasRelatedWork W1547591178 @default.
- W2023992918 hasRelatedWork W1936518725 @default.
- W2023992918 hasRelatedWork W2023992918 @default.
- W2023992918 hasRelatedWork W2041121024 @default.
- W2023992918 hasRelatedWork W2049665148 @default.
- W2023992918 hasRelatedWork W2083921861 @default.
- W2023992918 hasRelatedWork W2184290138 @default.
- W2023992918 hasRelatedWork W2410664263 @default.
- W2023992918 hasRelatedWork W2599978862 @default.
- W2023992918 hasRelatedWork W2885775080 @default.
- W2023992918 hasVolume "19" @default.
- W2023992918 isParatext "false" @default.
- W2023992918 isRetracted "false" @default.
- W2023992918 magId "2023992918" @default.
- W2023992918 workType "article" @default.