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- W2023992939 abstract "Hypertension, orthostatic hypotension, arterial insufficiency, and atherosclerosis are common disorders in the elderly that lead to significant morbidity and mortality. One common factor to these conditions is an age-related decline in vascular beta-adrenergic receptor-mediated function and subsequent cAMP generation. Presently, there is no single cellular factor that can explain this age-related decline, and thus, the primary cause of this homeostatic imbalance is yet to be identified. However, the etiology is clearly associated with an age-related change in the ability of beta-adrenergic receptor to respond to agonist at the cellular level in the vasculature. This paper will review what is presently understood regarding the molecular and biochemical basis of age-impaired beta-adrenergic receptor-mediated signaling. A fundamental understanding of why β -AR-mediated vasorelaxation is impaired with age will provide new insights and innovative strategies for the management of multiple clinical disorders." @default.
- W2023992939 created "2016-06-24" @default.
- W2023992939 creator A5044742922 @default.
- W2023992939 creator A5074975390 @default.
- W2023992939 date "2012-01-01" @default.
- W2023992939 modified "2023-09-25" @default.
- W2023992939 title "Biochemical and Molecular Aspects of Vascular Adrenergic Regulation of Blood Pressure in the Elderly" @default.
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- W2023992939 doi "https://doi.org/10.1155/2012/915057" @default.
- W2023992939 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3179865" @default.
- W2023992939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21961055" @default.
- W2023992939 hasPublicationYear "2012" @default.
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