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- W2023993146 abstract "Apurinic/apyrimidinic and oxidized abasic sites are chemically reactive DNA lesions that are produced by a variety of damaging agents. The effects of these molecules that lack a Watson-Crick base on polymerase enzymes are well documented. More recently, multiple consequences of the electrophilic nature of abasic lesions have been revealed. Members of this family of DNA lesions have been shown to inactivate repair enzymes and undergo spontaneous transformation into more deleterious forms of damage. Abasic site reactivity provides insight into the chemical basis for the cytotoxicity of DNA damaging agents that produce them and are valuable examples of how looking beneath the surface of seemingly simple molecules can reveal biologically relevant chemical complexity." @default.
- W2023993146 created "2016-06-24" @default.
- W2023993146 creator A5087642554 @default.
- W2023993146 date "2014-08-01" @default.
- W2023993146 modified "2023-10-16" @default.
- W2023993146 title "Looking beneath the surface to determine what makes DNA damage deleterious" @default.
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- W2023993146 doi "https://doi.org/10.1016/j.cbpa.2014.03.018" @default.
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