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- W2023995241 abstract "We have previously shown that, in experimentally inoculated mice, canine distemper virus (CDV), a neurotropic virus, selectively infects certain brain structures (hypothalamus, hippocampus, monoaminergic nuclei, etc). Here we demonstrate that tumor necrosis factor (TNF)-α, interleukin (IL)-1 β and IL-6 transcripts are selectively expressed in these CDV-targeted structures, except in the dentate gyrus, where cytokines are induced without prior CDV replication. The time-course of TNF-α expression vs. viral replication in the hypothalamus was different from that in hippocampus. In addition, we show that a substantial number of neurons express TNF-α and IL-6. These findings provide new insights into the possible participation of cytokines in the neurological disorders triggered by CDV infection." @default.
- W2023995241 created "2016-06-24" @default.
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- W2023995241 date "1996-03-01" @default.
- W2023995241 modified "2023-09-23" @default.
- W2023995241 title "Selective induction of cytokines in mouse brain infected with canine distemper virus: structural, cellular and temporal expression" @default.
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- W2023995241 doi "https://doi.org/10.1016/0165-5728(95)00173-5" @default.
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