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• W2023996564 abstract "Purpose of review Obesity is associated with low-grade chronic inflammation in adipose tissue. This review presents an update on human and rodent studies analyzing the nature of fat-infiltrating immune cells, the time course of adipose tissue infiltration and underlying mechanisms. Recent findings Intensive studies in rodents have shown that not only cells of the innate immune system traffic into adipose tissue but also various lymphocytes of the adaptive immunity are involved in inflammatory processes in fat. Several studies also provide insight in the order of appearance of macrophages and lymphocytes during the onset of obesity. Adipocytes and preadipocytes are also active players by their secretion of chemotactic adipokines. Summary This review summarizes strong evidence for a link between the action of innate and adaptive immune systems in adipose tissue in the context of obesity and metabolism in rodents, but more studies in humans are necessary to relate this topic to human physiology. Targeting different immune cells at different stages of obesity may eventually lead to novel therapeutic approaches for the metabolic syndrome." @default.
• W2023996564 created "2016-06-24" @default.
• W2023996564 creator A5020607761 @default.
• W2023996564 creator A5031987417 @default.
• W2023996564 date "2010-07-01" @default.
• W2023996564 modified "2023-10-18" @default.
• W2023996564 title "Adipose tissue inflammation: novel insight into the role of macrophages and lymphocytes" @default.
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• W2023996564 doi "https://doi.org/10.1097/mco.0b013e32833aab7f" @default.
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