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• W2023996613 endingPage "1506" @default.
• W2023996613 startingPage "1503" @default.
• W2023996613 abstract "Hormone-sensitive lipase, a key enzyme in fatty acid mobilization, overall energy homeostasis, and possibly steroidogenesis, is acutely controlled through reversible phosphorylation by catecholamines and insulin. The 757-amino acid sequence predicted from a cloned rat adipocyte complementary DNA showed no homology with any other known lipase or protein. The activity-controlling phosphorylation site was localized to Ser563 in a markedly hydrophilic domain, and a lipid-binding consensus site was tentatively identified. One or several messenger RNA species (3.3, 3.5, or 3.9 kilobases) were expressed in adipose and steroidogenic tissues and heart and skeletal muscle. The human hormone-sensitive lipase gene mapped to chromosome 19 cent-q13.3." @default.
• W2023996613 created "2016-06-24" @default.
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• W2023996613 date "1988-09-16" @default.
• W2023996613 modified "2023-09-25" @default.
• W2023996613 title "Hormone-Sensitive Lipase: Sequence, Expression, and Chromosomal Localization to 19 cent-q13.3" @default.
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• W2023996613 doi "https://doi.org/10.1126/science.3420405" @default.
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