Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023998313> ?p ?o ?g. }
- W2023998313 endingPage "213" @default.
- W2023998313 startingPage "203" @default.
- W2023998313 abstract "Summary: We are often taught that secondary, or memory, responses by lymphocytes are more vigorous than primary responses. An expectation commonly associated with this notion is that the initial encounter with a pathogen should result in immunity to re‐infection. Although this outcome is sometimes the case, it is not universally true. In this review, we propose a unified model of T‐cell memory to explain the apparent successes and failures of eliciting vaccine‐like protection from prior encounters with pathogens. We speculate that memory T cells arise as an invariant consequence of clonal selection during an immune response. The quality of memory T cells, however, seems to vary in the degree to which they have acquired effector characteristics and, thus, their ability to confer immunity to re‐infection. Although not all memory T cells possess the embellished attributes of fully developed effector cells, they all seem to share the rudimentary quality of preserving an antigen specificity that has proven itself useful. We suggest that the ability to maintain the integrity of the T‐cell repertoire, more than establishing immunity to re‐infection, may represent the fundamental form of memory for the adaptive immune system." @default.
- W2023998313 created "2016-06-24" @default.
- W2023998313 creator A5042981870 @default.
- W2023998313 creator A5048688337 @default.
- W2023998313 creator A5057824723 @default.
- W2023998313 date "2006-06-01" @default.
- W2023998313 modified "2023-10-03" @default.
- W2023998313 title "Not‐so‐great expectations: re‐assessing the essence of T‐cell memory" @default.
- W2023998313 cites W1484537608 @default.
- W2023998313 cites W1491333606 @default.
- W2023998313 cites W1505315838 @default.
- W2023998313 cites W1518656192 @default.
- W2023998313 cites W1547859938 @default.
- W2023998313 cites W1548587525 @default.
- W2023998313 cites W1601504908 @default.
- W2023998313 cites W1602273859 @default.
- W2023998313 cites W1603412780 @default.
- W2023998313 cites W1603553128 @default.
- W2023998313 cites W1603918837 @default.
- W2023998313 cites W1908616178 @default.
- W2023998313 cites W1911902366 @default.
- W2023998313 cites W1927814499 @default.
- W2023998313 cites W1931750338 @default.
- W2023998313 cites W1964741953 @default.
- W2023998313 cites W1967261754 @default.
- W2023998313 cites W1972626855 @default.
- W2023998313 cites W1974489930 @default.
- W2023998313 cites W1974842026 @default.
- W2023998313 cites W1974906492 @default.
- W2023998313 cites W1976785514 @default.
- W2023998313 cites W1981480494 @default.
- W2023998313 cites W1995062641 @default.
- W2023998313 cites W2006645462 @default.
- W2023998313 cites W2008366157 @default.
- W2023998313 cites W2008794642 @default.
- W2023998313 cites W2021373422 @default.
- W2023998313 cites W2023396531 @default.
- W2023998313 cites W2025484368 @default.
- W2023998313 cites W2029128444 @default.
- W2023998313 cites W2031979870 @default.
- W2023998313 cites W2038067604 @default.
- W2023998313 cites W2038077689 @default.
- W2023998313 cites W2042250320 @default.
- W2023998313 cites W2056376302 @default.
- W2023998313 cites W2057138015 @default.
- W2023998313 cites W2064008537 @default.
- W2023998313 cites W2064656497 @default.
- W2023998313 cites W2067648924 @default.
- W2023998313 cites W2069340283 @default.
- W2023998313 cites W2070552972 @default.
- W2023998313 cites W2073848442 @default.
- W2023998313 cites W2077884399 @default.
- W2023998313 cites W2082400961 @default.
- W2023998313 cites W2090708870 @default.
- W2023998313 cites W2090831287 @default.
- W2023998313 cites W2091301099 @default.
- W2023998313 cites W2094092039 @default.
- W2023998313 cites W2101099764 @default.
- W2023998313 cites W2102810679 @default.
- W2023998313 cites W2105381977 @default.
- W2023998313 cites W2106950264 @default.
- W2023998313 cites W2110459643 @default.
- W2023998313 cites W2112552541 @default.
- W2023998313 cites W2114263643 @default.
- W2023998313 cites W2115785513 @default.
- W2023998313 cites W2118988718 @default.
- W2023998313 cites W2119319172 @default.
- W2023998313 cites W2126815715 @default.
- W2023998313 cites W2128243696 @default.
- W2023998313 cites W2128475635 @default.
- W2023998313 cites W2131544109 @default.
- W2023998313 cites W2131748930 @default.
- W2023998313 cites W2132956923 @default.
- W2023998313 cites W2133567701 @default.
- W2023998313 cites W2134916334 @default.
- W2023998313 cites W2137478600 @default.
- W2023998313 cites W2139412010 @default.
- W2023998313 cites W2139461240 @default.
- W2023998313 cites W2144304716 @default.
- W2023998313 cites W2146824956 @default.
- W2023998313 cites W2150492554 @default.
- W2023998313 cites W2159230898 @default.
- W2023998313 cites W2160927866 @default.
- W2023998313 cites W2162543584 @default.
- W2023998313 cites W2163001100 @default.
- W2023998313 cites W2165112338 @default.
- W2023998313 cites W2170904230 @default.
- W2023998313 cites W2293648610 @default.
- W2023998313 cites W4211183651 @default.
- W2023998313 cites W4242765117 @default.
- W2023998313 cites W4313309920 @default.
- W2023998313 cites W4361772937 @default.
- W2023998313 doi "https://doi.org/10.1111/j.0105-2896.2006.00396.x" @default.
- W2023998313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16824129" @default.
- W2023998313 hasPublicationYear "2006" @default.
- W2023998313 type Work @default.
- W2023998313 sameAs 2023998313 @default.
- W2023998313 citedByCount "26" @default.