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- W2023998905 abstract "The effect of hydroperoxy and hydroxy derivatives of various fatty acids on human platelet aggregation was determined to delineate potencies and structure-activity function. In this regard, the 22-carbon n-3 fatty acids are the most potent inhibitors in comparison to the n-6 lipoxygenase derivatives. Submicromolar levels of the docosapentaenoic (22:5) and especially docosahexaenoic (22:6) n-3 hydroperoxy and hydroxy derivatives specifically antagonize the platelet aggregating effect to arachidonic acid (AA, 20:4n-6) but not that of ADP or collagen. Chain length (22-C>20-C), double-bond position (n-3>n-6), and double-bond number (6>5>4) influence the degree of inhibition of AA-induced aggregation of human platelets. Moreover, significant differneces in potency were associated with specific structural aspects of 22:6n-3 lipoxygenase derivatives of 22:6n-3 as follows: functional group (OOH >OH) and positional isomer (14-OOH, 14-OH, 20-OOH>11-OOH, 17-OOH>10-OOH>11-OH, 8-OOH, 7-OOH>4-OOH)." @default.
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- W2023998905 date "1996-03-01" @default.
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- W2023998905 title "The structure-activity relationship of lipoxygenase products of long-chain polyunsaturated fatty acids: Effects on human platelet aggregation" @default.
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- W2023998905 doi "https://doi.org/10.1007/bf02637097" @default.
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