FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023998996> ?p ?o ?g. }

• W2023998996 endingPage "258" @default.
• W2023998996 startingPage "241" @default.
• W2023998996 abstract "In order to perform environmental risk assessments with regard to oil contamination in the sea, it is important to obtain knowledge about threshold levels for possible adverse effects in marine organisms. With this objective in mind, selected biomarkers were studied in Atlantic cod (Gadus morhua) chronically exposed to mechanically dispersed crude oil. The fish were exposed for 30 days in a continuous flow system to nominal concentrations of 0.06, 0.25 and 1 ppm North Sea crude oil. Fish were sampled five times during the exposure period. In addition, the 1 ppm group and the control group were sampled 1 week after the end of exposure. Polyaromatic hydrocarbon (PAH) concentrations in the seawater were analysed regularly by direct fluorescence and, at one occasion, by gas chromatography with mass spectrographic detection (GC/MS) measurements. Liver samples were analysed for parent PAH levels by means of GC/MS measurements, and PAH metabolites in bile were analysed by means of fixed wavelength fluorescence. Cytochrome P450 induction in liver was estimated by ethoxyresorufin-O-deethylase (EROD) activity, and hepatic DNA adducts were analysed by the 32P-postlabelling assay. The parent PAH concentrations in liver showed peak levels 3 days after the start of exposure, followed by a reduction towards the end of the experiment. In contrast, the PAH metabolites in bile and EROD activity showed generally increasing levels throughout the whole exposure period, indicating an increased biotransformation efficiency. The level of DNA adducts in the 1 ppm group showed a stable increase during the entire exposure period. Only a slight, non-significant decrease in DNA adduct levels was observed after 7 days of recovery in clean water. Exposure-dependent responses were observed for all three biomarkers. The lowest nominal concentration of dispersed oil in water, 0.06 ppm, corresponded to a measured total PAH concentration in the water of 0.3 ppb. Atlantic cod exposed to this concentration showed increased levels of PAH metabolites in bile and a slight induction of CYP1A, as well as formation of DNA adducts when compared with control fish. Particularly noteworthy is the detection of DNA adducts at such a low exposure concentration of oil in water, which, to our knowledge, is a novel finding. These dose-response data may serve as useful contributions when assessing environmental risk with regard to marine oil pollution." @default.
• W2023998996 created "2016-06-24" @default.
• W2023998996 creator A5036679836 @default.
• W2023998996 creator A5043353295 @default.
• W2023998996 creator A5050068874 @default.
• W2023998996 creator A5058329600 @default.
• W2023998996 creator A5065804390 @default.
• W2023998996 date "2000-12-01" @default.
• W2023998996 modified "2023-09-30" @default.
• W2023998996 title "PAH metabolites in bile, cytochrome P4501A and DNA adducts as environmental risk parameters for chronic oil exposure: a laboratory experiment with Atlantic cod" @default.
• W2023998996 cites W1564713431 @default.
• W2023998996 cites W1919420982 @default.
• W2023998996 cites W1965536658 @default.
• W2023998996 cites W1968659016 @default.
• W2023998996 cites W1969089933 @default.
• W2023998996 cites W1972487517 @default.
• W2023998996 cites W1974557903 @default.
• W2023998996 cites W1977753730 @default.
• W2023998996 cites W1978603648 @default.
• W2023998996 cites W1982344423 @default.
• W2023998996 cites W1984325207 @default.
• W2023998996 cites W1987143065 @default.
• W2023998996 cites W1988059026 @default.
• W2023998996 cites W1990062495 @default.
• W2023998996 cites W1996296647 @default.
• W2023998996 cites W2001221525 @default.
• W2023998996 cites W2001773212 @default.
• W2023998996 cites W2002293394 @default.
• W2023998996 cites W2010970227 @default.
• W2023998996 cites W2020597160 @default.
• W2023998996 cites W2024502335 @default.
• W2023998996 cites W2028425730 @default.
• W2023998996 cites W2029407625 @default.
• W2023998996 cites W2029643545 @default.
• W2023998996 cites W2031374445 @default.
• W2023998996 cites W2032362137 @default.
• W2023998996 cites W2033332361 @default.
• W2023998996 cites W2051677810 @default.
• W2023998996 cites W2052193954 @default.
• W2023998996 cites W2054827007 @default.
• W2023998996 cites W2058918620 @default.
• W2023998996 cites W2060852637 @default.
• W2023998996 cites W2064173587 @default.
• W2023998996 cites W2064372708 @default.
• W2023998996 cites W2064532832 @default.
• W2023998996 cites W2065969542 @default.
• W2023998996 cites W2071970988 @default.
• W2023998996 cites W2083299186 @default.
• W2023998996 cites W2095006411 @default.
• W2023998996 cites W2096106715 @default.
• W2023998996 cites W2118228522 @default.
• W2023998996 cites W2122636743 @default.
• W2023998996 cites W2125491749 @default.
• W2023998996 cites W2128442121 @default.
• W2023998996 cites W2152078624 @default.
• W2023998996 cites W2165444384 @default.
• W2023998996 cites W2168526937 @default.
• W2023998996 cites W2315793253 @default.
• W2023998996 cites W4251691407 @default.
• W2023998996 cites W4254894726 @default.
• W2023998996 cites W4293247451 @default.
• W2023998996 doi "https://doi.org/10.1016/s0166-445x(00)00108-9" @default.
• W2023998996 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11064127" @default.
• W2023998996 hasPublicationYear "2000" @default.
• W2023998996 type Work @default.
• W2023998996 sameAs 2023998996 @default.
• W2023998996 citedByCount "333" @default.
• W2023998996 countsByYear W20239989962012 @default.
• W2023998996 countsByYear W20239989962013 @default.
• W2023998996 countsByYear W20239989962014 @default.
• W2023998996 countsByYear W20239989962015 @default.
• W2023998996 countsByYear W20239989962016 @default.
• W2023998996 countsByYear W20239989962017 @default.
• W2023998996 countsByYear W20239989962018 @default.
• W2023998996 countsByYear W20239989962019 @default.
• W2023998996 countsByYear W20239989962020 @default.
• W2023998996 countsByYear W20239989962021 @default.
• W2023998996 countsByYear W20239989962022 @default.
• W2023998996 countsByYear W20239989962023 @default.
• W2023998996 crossrefType "journal-article" @default.
• W2023998996 hasAuthorship W2023998996A5036679836 @default.
• W2023998996 hasAuthorship W2023998996A5043353295 @default.
• W2023998996 hasAuthorship W2023998996A5050068874 @default.
• W2023998996 hasAuthorship W2023998996A5058329600 @default.
• W2023998996 hasAuthorship W2023998996A5065804390 @default.
• W2023998996 hasConcept C107872376 @default.
• W2023998996 hasConcept C114246631 @default.
• W2023998996 hasConcept C178790620 @default.
• W2023998996 hasConcept C181199279 @default.
• W2023998996 hasConcept C185592680 @default.
• W2023998996 hasConcept C2777883778 @default.
• W2023998996 hasConcept C2778959862 @default.
• W2023998996 hasConcept C2779033964 @default.
• W2023998996 hasConcept C2779428213 @default.
• W2023998996 hasConcept C2781247443 @default.
• W2023998996 hasConcept C27881333 @default.
• W2023998996 hasConcept C2909208804 @default.
• W2023998996 hasConcept C29730261 @default.

• next