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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023999933> ?p ?o ?g. }

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• W2023999933 abstract "Apoptosis is a cell death program involved in the development of multicellular organisms, immunity, and pathologies ranging from cancer to HIV/AIDS. We present an engineered protein that causes rapid apoptosis of targeted cells in monolayer culture after stimulation with blue light. Cells transfected with the protein switch L57V, a tandem fusion of the light-sensing LOV2 domain and the apoptosis-executing domain from caspase-7, rapidly undergo apoptosis within 60 min after light stimulation. Constant illumination of under 5 min or oscillating with 1 min exposure had no effect, suggesting that cells have natural tolerance to a short duration of caspase-7 activity. Furthermore, the overexpression of Bcl-2 prevented L57V-mediated apoptosis, suggesting that although caspase-7 activation is sufficient to start apoptosis, it requires mitochondrial contribution to fully commit." @default.
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• W2023999933 date "2011-11-04" @default.
• W2023999933 modified "2023-10-17" @default.
• W2023999933 title "Engineering a Photoactivated Caspase-7 for Rapid Induction of Apoptosis" @default.
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• W2023999933 doi "https://doi.org/10.1021/sb200008j" @default.
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