Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023999940> ?p ?o ?g. }
- W2023999940 endingPage "82" @default.
- W2023999940 startingPage "74" @default.
- W2023999940 abstract "Mesenchymal stem cells (MSCs) and pluripotent stem cells (PSCs) emerge as promising tools for tissue engineering, cell therapy, and drug screening. Their potential use in clinical applications requires the efficient production of differentiated cells at large scale. Glucose, amino acid, and oxygen metabolism play a key role in MSC and PSC expansion and differentiation. This review summarizes recent advances in the understanding of stem cell metabolism for reprogramming, self-renewal, and lineage commitment. From the reported data, efficient expansion of stem cells has been found to rely on glycolysis, while during differentiation stem cells shift their metabolic pathway to oxidative phosphorylation. During reprogramming, the reverse metabolic shift from oxidative phosphorylation to glycolysis has been observed. As a consequence, the demands for glucose and oxygen vary upon different phases of stem cell production. Accurate understanding of stem cell metabolism is critical for the rational design of culture parameters such as oxygen tension and feeding regime in bioreactors towards efficient integrated reprogramming, expansion, and differentiation processes at large scale." @default.
- W2023999940 created "2016-06-24" @default.
- W2023999940 creator A5032024543 @default.
- W2023999940 creator A5046624620 @default.
- W2023999940 creator A5059852869 @default.
- W2023999940 date "2014-03-01" @default.
- W2023999940 modified "2023-09-27" @default.
- W2023999940 title "Process engineering of stem cell metabolism for large scale expansion and differentiation in bioreactors" @default.
- W2023999940 cites W1502442150 @default.
- W2023999940 cites W1603561668 @default.
- W2023999940 cites W1717188909 @default.
- W2023999940 cites W1874303456 @default.
- W2023999940 cites W1894559552 @default.
- W2023999940 cites W1964324925 @default.
- W2023999940 cites W1965653791 @default.
- W2023999940 cites W1965738390 @default.
- W2023999940 cites W1967366984 @default.
- W2023999940 cites W1969166539 @default.
- W2023999940 cites W1969867532 @default.
- W2023999940 cites W1970288681 @default.
- W2023999940 cites W1970692048 @default.
- W2023999940 cites W1970809958 @default.
- W2023999940 cites W1971063609 @default.
- W2023999940 cites W1972925834 @default.
- W2023999940 cites W1973983046 @default.
- W2023999940 cites W1975371675 @default.
- W2023999940 cites W1978603428 @default.
- W2023999940 cites W1979172728 @default.
- W2023999940 cites W1980026529 @default.
- W2023999940 cites W1981296999 @default.
- W2023999940 cites W1982354058 @default.
- W2023999940 cites W1984652179 @default.
- W2023999940 cites W1985098418 @default.
- W2023999940 cites W1986500594 @default.
- W2023999940 cites W1987715868 @default.
- W2023999940 cites W1987983362 @default.
- W2023999940 cites W1990779770 @default.
- W2023999940 cites W1991504547 @default.
- W2023999940 cites W1992816164 @default.
- W2023999940 cites W1992996571 @default.
- W2023999940 cites W1995833967 @default.
- W2023999940 cites W1998309543 @default.
- W2023999940 cites W1998827276 @default.
- W2023999940 cites W2000721992 @default.
- W2023999940 cites W2002043863 @default.
- W2023999940 cites W2002198698 @default.
- W2023999940 cites W2002828554 @default.
- W2023999940 cites W2003762441 @default.
- W2023999940 cites W2010618607 @default.
- W2023999940 cites W2015831230 @default.
- W2023999940 cites W2017720509 @default.
- W2023999940 cites W2018013954 @default.
- W2023999940 cites W2018504915 @default.
- W2023999940 cites W2020521709 @default.
- W2023999940 cites W2024137198 @default.
- W2023999940 cites W2025192477 @default.
- W2023999940 cites W2025371271 @default.
- W2023999940 cites W2029920142 @default.
- W2023999940 cites W2032656636 @default.
- W2023999940 cites W2033471108 @default.
- W2023999940 cites W2038231474 @default.
- W2023999940 cites W2039752612 @default.
- W2023999940 cites W2043436613 @default.
- W2023999940 cites W2043457504 @default.
- W2023999940 cites W2043814008 @default.
- W2023999940 cites W2044367175 @default.
- W2023999940 cites W2051070943 @default.
- W2023999940 cites W2052620919 @default.
- W2023999940 cites W2054216387 @default.
- W2023999940 cites W2056077438 @default.
- W2023999940 cites W2057732983 @default.
- W2023999940 cites W2058544514 @default.
- W2023999940 cites W2059118487 @default.
- W2023999940 cites W2059223857 @default.
- W2023999940 cites W2059413563 @default.
- W2023999940 cites W2059605159 @default.
- W2023999940 cites W2063265877 @default.
- W2023999940 cites W2063321848 @default.
- W2023999940 cites W2072719397 @default.
- W2023999940 cites W2074061707 @default.
- W2023999940 cites W2076289226 @default.
- W2023999940 cites W2076744990 @default.
- W2023999940 cites W2078266417 @default.
- W2023999940 cites W2079697285 @default.
- W2023999940 cites W2084391077 @default.
- W2023999940 cites W2084605980 @default.
- W2023999940 cites W2086943348 @default.
- W2023999940 cites W2090321067 @default.
- W2023999940 cites W2092181208 @default.
- W2023999940 cites W2092364499 @default.
- W2023999940 cites W2097259163 @default.
- W2023999940 cites W2101569447 @default.
- W2023999940 cites W2101967659 @default.
- W2023999940 cites W2109550021 @default.
- W2023999940 cites W2111993114 @default.
- W2023999940 cites W2113612475 @default.
- W2023999940 cites W2122449012 @default.
- W2023999940 cites W2127953110 @default.