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- W2024001433 abstract "Until recently, hepatorenal syndrome (HRS), a severe complication of advanced liver failure, has been orphan of an effective therapy. Since intrarenal vasoconstriction was the recognized hallmark of patients with HRS [ [1] Epstein M. Berk D.P. Hollemberg N.K. Adams D.F. Chalmers T. Abrams H.L. et al. Renal failure in the patient with cirrhosis. The role of active vasoconstriction. Am J Med. 1970; 49: 175-185 Abstract Full Text PDF PubMed Scopus (380) Google Scholar ], any previous attempts of therapy were addressed to vasodilate the kidney vascular bed with low-dose dopamine [ [2] Wilson J.R. Dopamine in the hepatorenal syndrome. JAMA. 1977; 238: 2719-2720 Crossref PubMed Scopus (23) Google Scholar ] or other vasodilator drugs such as Captopril [ [3] Daskalopoulos G. Pinzani M. Murray N. Hirschberg R. Zipser R.D. Effects of captopril on renal function in patients with cirrhosis and ascites. J Hepatol. 1987; 4: 330-336 Abstract Full Text PDF PubMed Scopus (40) Google Scholar ]. All these attempts failed, however, due to the lack of a selective renal effect, and liver transplantation was the unique effective rescue, although it could be performed in a very few cases." @default.
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- W2024001433 date "2007-11-01" @default.
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- W2024001433 title "Pharmacological treatment of hepatorenal syndrome: A note of optimism" @default.
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- W2024001433 doi "https://doi.org/10.1016/j.jhep.2007.08.004" @default.
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