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- W2024004004 abstract "Trans-dominant mutants of human immunodeficiency virus type 1 (HIV-1) Tat and Rev are attractive candidates for use in gene therapy in the treatment of HIV-1 infections because both are essential for viral replication. Retroviral vectors were constructed to allow either Tat-inducible or Tat- and Rev-inducible expression of trans-dominant mutants of Tat and Rev. These vectors were used to infect a human CD4+ lymphocyte-derived cell line, MT4. To determine the efficacy of various Tat and Rev mutants in inhibiting HIV-1 multiplication, MT4 cells containing mutant-expressing constructs were infected with HIV-1, and the amount of HIV-1 released in the culture medium was measured for up to 30 days. A high level of resistance was observed in cells expressing the double tat/rev mutant in a Tat-inducible manner." @default.
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- W2024004004 date "1993-10-01" @default.
- W2024004004 modified "2023-10-10" @default.
- W2024004004 title "The Development and Testing of Retroviral Vectors Expressing<i>Trans</i>-Dominant Mutants of HIV-1 Proteins to Confer Anti-HIV-1 Resistance" @default.
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- W2024004004 doi "https://doi.org/10.1089/hum.1993.4.5-625" @default.
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