FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024006134> ?p ?o ?g. }

• W2024006134 endingPage "2812" @default.
• W2024006134 startingPage "2802" @default.
• W2024006134 abstract "ABSTRACT The glycoprotein (g) complex gH/gL represents an essential part of the herpesvirus fusion machinery mediating entry of cell-free virions and cell-associated viral spread. In some herpesviruses additional proteins are associated with gH/gL contributing to the cell tropism of the respective virus. Human cytomegalovirus (HCMV) gH/gL forms complexes with either gO (UL74) or proteins of the UL128-131A gene locus. While a contribution of UL128-131A to endothelial cell tropism is known, the role of gO is less clear. We studied the role of gH/gL-associated proteins in HCMV replication in human foreskin fibroblasts (HFF) and human umbilical vein endothelial cells (HUVEC). Deletions of UL74 alone or in combination with mutations of the UL128-131A gene region were introduced into bacterial artificial chromosome vectors derived from the endotheliotropic strain TB40/E. Deletion of UL74 caused a profound defect regarding virus release from infected HFF and HUVEC. Large numbers of capsids accumulated in the cytoplasm of infected HFF but failed to acquire an envelope. Clear cell type differences were observed in the cell-associated spread of the UL74-defective virus. In HFF, focal growth was severely impaired, whereas it was normal in HUVEC. Deletion of UL131A abolished focal growth in endothelial cells. UL74/UL128-131A dual mutants showed severely impaired reconstitution efficiency. Our data suggest that gO plays a critical role in secondary envelopment and release of cell-free virions independent of the cell type but affects cell-associated growth specifically in HFF, whereas UL128-131A contributes to cell-associated spread in HFF and HUVEC." @default.
• W2024006134 created "2016-06-24" @default.
• W2024006134 creator A5009844097 @default.
• W2024006134 creator A5010755577 @default.
• W2024006134 creator A5014729463 @default.
• W2024006134 creator A5034738118 @default.
• W2024006134 creator A5045167269 @default.
• W2024006134 creator A5067295491 @default.
• W2024006134 creator A5067607487 @default.
• W2024006134 creator A5070304125 @default.
• W2024006134 creator A5084343882 @default.
• W2024006134 creator A5087523867 @default.
• W2024006134 creator A5091738462 @default.
• W2024006134 date "2008-03-15" @default.
• W2024006134 modified "2023-10-15" @default.
• W2024006134 title "UL74 of Human Cytomegalovirus Contributes to Virus Release by Promoting Secondary Envelopment of Virions" @default.
• W2024006134 cites W1708005027 @default.
• W2024006134 cites W1971041498 @default.
• W2024006134 cites W1980312737 @default.
• W2024006134 cites W1985887381 @default.
• W2024006134 cites W1994882633 @default.
• W2024006134 cites W2014361215 @default.
• W2024006134 cites W2029345949 @default.
• W2024006134 cites W2030172852 @default.
• W2024006134 cites W2050459186 @default.
• W2024006134 cites W2065197515 @default.
• W2024006134 cites W2070907961 @default.
• W2024006134 cites W2075517421 @default.
• W2024006134 cites W2080780046 @default.
• W2024006134 cites W2096963698 @default.
• W2024006134 cites W2097882890 @default.
• W2024006134 cites W2106604059 @default.
• W2024006134 cites W2118937969 @default.
• W2024006134 cites W2121482544 @default.
• W2024006134 cites W2128159409 @default.
• W2024006134 cites W2133533422 @default.
• W2024006134 cites W2138357022 @default.
• W2024006134 cites W2141755034 @default.
• W2024006134 cites W2142404794 @default.
• W2024006134 cites W2153481391 @default.
• W2024006134 cites W2153924587 @default.
• W2024006134 cites W2159702641 @default.
• W2024006134 cites W2160245647 @default.
• W2024006134 cites W2162867040 @default.
• W2024006134 cites W2168846694 @default.
• W2024006134 cites W2170764608 @default.
• W2024006134 cites W2413193624 @default.
• W2024006134 doi "https://doi.org/10.1128/jvi.01550-07" @default.
• W2024006134 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2259017" @default.
• W2024006134 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18184717" @default.
• W2024006134 hasPublicationYear "2008" @default.
• W2024006134 type Work @default.
• W2024006134 sameAs 2024006134 @default.
• W2024006134 citedByCount "98" @default.
• W2024006134 countsByYear W20240061342012 @default.
• W2024006134 countsByYear W20240061342013 @default.
• W2024006134 countsByYear W20240061342014 @default.
• W2024006134 countsByYear W20240061342015 @default.
• W2024006134 countsByYear W20240061342016 @default.
• W2024006134 countsByYear W20240061342017 @default.
• W2024006134 countsByYear W20240061342018 @default.
• W2024006134 countsByYear W20240061342019 @default.
• W2024006134 countsByYear W20240061342020 @default.
• W2024006134 countsByYear W20240061342021 @default.
• W2024006134 countsByYear W20240061342022 @default.
• W2024006134 countsByYear W20240061342023 @default.
• W2024006134 crossrefType "journal-article" @default.
• W2024006134 hasAuthorship W2024006134A5009844097 @default.
• W2024006134 hasAuthorship W2024006134A5010755577 @default.
• W2024006134 hasAuthorship W2024006134A5014729463 @default.
• W2024006134 hasAuthorship W2024006134A5034738118 @default.
• W2024006134 hasAuthorship W2024006134A5045167269 @default.
• W2024006134 hasAuthorship W2024006134A5067295491 @default.
• W2024006134 hasAuthorship W2024006134A5067607487 @default.
• W2024006134 hasAuthorship W2024006134A5070304125 @default.
• W2024006134 hasAuthorship W2024006134A5084343882 @default.
• W2024006134 hasAuthorship W2024006134A5087523867 @default.
• W2024006134 hasAuthorship W2024006134A5091738462 @default.
• W2024006134 hasBestOaLocation W20240061341 @default.
• W2024006134 hasConcept C132787861 @default.
• W2024006134 hasConcept C140704245 @default.
• W2024006134 hasConcept C1491633281 @default.
• W2024006134 hasConcept C159047783 @default.
• W2024006134 hasConcept C189014844 @default.
• W2024006134 hasConcept C190062978 @default.
• W2024006134 hasConcept C2522874641 @default.
• W2024006134 hasConcept C2779820661 @default.
• W2024006134 hasConcept C2781196997 @default.
• W2024006134 hasConcept C33602714 @default.
• W2024006134 hasConcept C35693153 @default.
• W2024006134 hasConcept C54355233 @default.
• W2024006134 hasConcept C58475186 @default.
• W2024006134 hasConcept C86803240 @default.
• W2024006134 hasConcept C92488253 @default.
• W2024006134 hasConcept C95444343 @default.
• W2024006134 hasConcept C97380033 @default.
• W2024006134 hasConceptScore W2024006134C132787861 @default.
• W2024006134 hasConceptScore W2024006134C140704245 @default.

• next