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- W2024008046 abstract "Atrial fibrillation (AF) is the most common tachyarrhythmia in humans. It causes palpitations, decreased cardiac output, heart failure and systemic thromboembolism, and is associated with significant morbidity, mortality1 and healthcare costs. Current treatment strategies for AF are far from satisfactory.Atrial fibrillation has a tendency to become more persistent with time, a large percentage of patients with paroxysmal AF eventually developing chronic AF.2 Although progression of an underlying disease has previously been considered as the most likely explanation for this phenomenon, in a proportion of cases, no underlying disease is evident. Recently Wijffels and coworkers have demonstrated, in a chronically instrumented conscious goat model, that episodes of AF may be self‐perpetuating (‘AF begets AF’) and have suggested that there may be a purely electrophysiological explanation (termed atrial electrical remodelling) for the increased persistence of AF with time.3 This hypothesis has considerable clinical importance in that it would, if proven, support a more aggressive approach to the overall management of AF. If AF leads to more AF, then it is reasonable to expect that earlier termination and preventative therapy for the arrhythmia would improve the long‐term outcome of patients with the condition.In the original model of Wijffels and Allessie,3 goats initially had electrodes sutured to the epicardium of both atria. After this initial surgery, the goats were connected to an external automatic fibrillator. The device was programmed to deliver a 1 s burst of electrical stimuli whenever sinus rhythm was sensed. In the normal animal, the first …" @default.
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- W2024008046 date "2000-09-01" @default.
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- W2024008046 title "Atrial electrical remodelling and atrial fibrillation" @default.
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- W2024008046 doi "https://doi.org/10.1093/qjmed/93.9.563" @default.
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