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- W2024008725 abstract "Previous experimental evidence has shown that neonatal exposure to morphine has lasting effects on pain thresholds and the density of opiate receptor sites in several brain regions (Handelmann & Quirion, European J Pharmac. , in press). In order to more clearly define the functional correlates of the altered distribution of opiate receptors, we chose the autoradiographic 14C Deoxyglucose method for measuring in vivo glucose utilization rates in brain tissue (Sokoloff et al., J Neurochemistry 28:897-916, 1977). Newborn albino rats were injected s.c. with lug morphine sulfate in 5ul phosphate buffered saline each day on postnatal days 1 through 7. The deoxyglucose experiments were performed after the rats were 3 months of age. The frozen brains were sectioned 20microns thick and used to produce images on Xray film. Optical densities were obtained using a computerized image processing system. Glucose utilization rates were altered in several brain regions when compared to control values. Notably the reduced glucose metabolic rate found in the dentate gyrus of the hippocampus correlated well with the altered density of opiate receptors in that structure." @default.
- W2024008725 created "2016-06-24" @default.
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- W2024008725 date "1984-04-01" @default.
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- W2024008725 title "GLUCOSE UTILIZATION IN ADULT RAT BRAIN FOLLOING NEONATAL TREATMENT WITH MORPHINE, A QUANTITATIVE AUTORADIOGRAPHIC STUDY" @default.
- W2024008725 doi "https://doi.org/10.1203/00006450-198404001-00353" @default.
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