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- W2024011370 abstract "Green approaches for efficient synthesis of quinazoline- and pyrimidine-2-amine derivatives were established based on the one-pot and three-component condensation of guanidine carbonate, cyclic ketones and aldehydes. These approaches involve the evaluation of the activity of several acidic ionic liquids (ILs) as organocatalysts under solvent-free medium in the microwave and as solvents and catalysts in the ultrasound irradiations. Reactions were evaluated for a number of substituted aldehydes and cyclic ketones on the basis of variation of parameters including type and amount of ILs, reaction temperature and time. Compared to the ultrasound method, the solvent-free procedure in the microwave was found to be more efficient in terms of both chemical yield and reaction time. Catalyst recyclability, simplicity, and time-saving aspects of the reaction suggests that these methods present real alternatives to conventional reaction protocols." @default.
- W2024011370 created "2016-06-24" @default.
- W2024011370 creator A5002137602 @default.
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- W2024011370 date "2014-11-01" @default.
- W2024011370 modified "2023-09-27" @default.
- W2024011370 title "Eco-safe and expeditious approaches for synthesis of quinazoline and pyrimidine-2-amine derivatives using ionic liquids aided with ultrasound or microwave irradiation" @default.
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- W2024011370 doi "https://doi.org/10.1016/j.molliq.2014.09.018" @default.
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