FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024012511> ?p ?o ?g. }

• W2024012511 endingPage "S360" @default.
• W2024012511 startingPage "S360" @default.
• W2024012511 abstract "Flow-mediated dilation (FMD) declines in the brachial artery (BA) with healthy aging in women. However, the physiological determinants of this decline are not welled fined, particularly after the BA FMD response has been normalized to the shear stress stimulus. Furthermore, it is not known whether this diminished FMD is seen in the leg vasculature (popliteal artery, PA), a more hemodynamically significant vascular bed utilized during ambulatory activities. PURPOSE To determine the characteristics and determinants of age-related changes in BA and PA FMD in healthy women. METHODS 41 normally active, healthy women (ages 20–79) were measured for variables including cycle VO2peak, body mass index (BMI) and regional muscle mass (forearm and calf). Resting PA and BA diameters and BA shear rate (SR= blood velocity/diameter, an estimate of shear stress) were measured prior to infiation of an upper arm or leg cuff to suprasystolic pressure for 10 min; post-occlusion diameter measurements and peak BA shear rate were used to calculate BA and PA dilation (% D = % change from baseline to peak diameter) and BA % D normalized to shear stimulus (% D/% change in SR from resting to peak). Simple linear regression was used to determine the age-associated changes in BA and PA FMD; forward/reverse stepwise linear regression was then used to determine the predictors of these age-related changes. RESULTS Resting BA and PA diameters did not differ with age (p>0.05). BA FMD normalized to shear stimulus declined 11.6% /decade with age (p <0.01); the strongest predictors of this decline were age, VO2peak, and forearm muscle mass (cumulative r2=.41; p=0.01). PA % D was not related to age (p>0.05). The only significant predictors of PA FMD were calf muscle mass (p=0.03, r2=.112) and BMI (p=0.03; r2=.121). CONCLUSION These results suggest that agerelated changes in the intrinsic dilator capacity of a conduit artery are limb-specific; additionally, the strong predictive ability of forearm flow-mediated dilation does not exist in the calf with predictors such as regional muscle mass and VO2peak. Supported by College of Health and Human Development Seed Grant #423-22" @default.
• W2024012511 created "2016-06-24" @default.
• W2024012511 creator A5041482139 @default.
• W2024012511 creator A5063265113 @default.
• W2024012511 creator A5086629429 @default.
• W2024012511 date "2005-05-01" @default.
• W2024012511 modified "2023-09-27" @default.
• W2024012511 title "Characteristics And Determinants Of Age-related Changes In Brachial And Popliteal Artery Flow-mediated Dilation In Women" @default.
• W2024012511 doi "https://doi.org/10.1097/00005768-200505001-01887" @default.
• W2024012511 hasPublicationYear "2005" @default.
• W2024012511 type Work @default.
• W2024012511 sameAs 2024012511 @default.
• W2024012511 citedByCount "0" @default.
• W2024012511 crossrefType "journal-article" @default.
• W2024012511 hasAuthorship W2024012511A5041482139 @default.
• W2024012511 hasAuthorship W2024012511A5063265113 @default.
• W2024012511 hasAuthorship W2024012511A5086629429 @default.
• W2024012511 hasBestOaLocation W20240125111 @default.
• W2024012511 hasConcept C105795698 @default.
• W2024012511 hasConcept C126322002 @default.
• W2024012511 hasConcept C141071460 @default.
• W2024012511 hasConcept C164705383 @default.
• W2024012511 hasConcept C2777303625 @default.
• W2024012511 hasConcept C2777604165 @default.
• W2024012511 hasConcept C2780214079 @default.
• W2024012511 hasConcept C33923547 @default.
• W2024012511 hasConcept C48921125 @default.
• W2024012511 hasConcept C71924100 @default.
• W2024012511 hasConcept C84393581 @default.
• W2024012511 hasConceptScore W2024012511C105795698 @default.
• W2024012511 hasConceptScore W2024012511C126322002 @default.
• W2024012511 hasConceptScore W2024012511C141071460 @default.
• W2024012511 hasConceptScore W2024012511C164705383 @default.
• W2024012511 hasConceptScore W2024012511C2777303625 @default.
• W2024012511 hasConceptScore W2024012511C2777604165 @default.
• W2024012511 hasConceptScore W2024012511C2780214079 @default.
• W2024012511 hasConceptScore W2024012511C33923547 @default.
• W2024012511 hasConceptScore W2024012511C48921125 @default.
• W2024012511 hasConceptScore W2024012511C71924100 @default.
• W2024012511 hasConceptScore W2024012511C84393581 @default.
• W2024012511 hasIssue "Supplement" @default.
• W2024012511 hasLocation W20240125111 @default.
• W2024012511 hasOpenAccess W2024012511 @default.
• W2024012511 hasPrimaryLocation W20240125111 @default.
• W2024012511 hasRelatedWork W2067655132 @default.
• W2024012511 hasRelatedWork W2083572738 @default.
• W2024012511 hasRelatedWork W2089351189 @default.
• W2024012511 hasRelatedWork W2129443348 @default.
• W2024012511 hasRelatedWork W2146349004 @default.
• W2024012511 hasRelatedWork W2942928505 @default.
• W2024012511 hasRelatedWork W4239645313 @default.
• W2024012511 hasRelatedWork W4242400218 @default.
• W2024012511 hasRelatedWork W4252480204 @default.
• W2024012511 hasRelatedWork W4254940888 @default.
• W2024012511 hasVolume "37" @default.
• W2024012511 isParatext "false" @default.
• W2024012511 isRetracted "false" @default.
• W2024012511 magId "2024012511" @default.
• W2024012511 workType "article" @default.