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• W2024012952 abstract "To synthesize a biotin radiopharmaceutical that clears rapidly, dendrimer was used as a carrier and conjugated with succinimidyl 3-[(125)I]iodobenzoate and tetrafluorophenyl norbiotinamidosuccinate. Then, succinic anhydride was used to reduce its pI. In mice, the non-succinylated product showed high liver (67% ID/g) and kidney (44% ID/g) uptakes and whole-body retention (94% ID) at 20 min that persisted for 12 hr. The corresponding organ uptakes (22% and 11% ID/g) and the whole-body retention (47% ID) were drastically reduced by succinylation (p<0.0001). Lysine co-injection further lowered renal uptake." @default.
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• W2024012952 date "2003-08-01" @default.
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• W2024012952 title "Synthesis of dendrimer-based biotin radiopharmaceuticals to enhance whole-body clearance" @default.
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• W2024012952 doi "https://doi.org/10.1016/s0969-8051(03)00052-0" @default.
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