Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024013035> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W2024013035 endingPage "477" @default.
- W2024013035 startingPage "473" @default.
- W2024013035 abstract "Differential effects on the proliferation of individual vs. combined administration of high-and lowmolecular-weight microbial autoregulators (extracellular RNase fromBacillus intermedius and anabiosis inducing factord 1) are reported for the first time for cultured cells of higher eukaryotes. Proliferation ofras- transformed mouse fibroblasts was affected by both autoregulators dose-dependently. The cytotoxic activity of individual regulators was directly related to their concentration. Unlike RNase, factord 1 (which functions as a chemical chaperone) exerted reversible effects. Studies of the effects of combined administration of the autoregulators demonstrated that pretreatment of the cells with low-dosed 1 decreased the toxicity of RNase. Higher doses ofd 1 were required to attenuate the effects of toxic agents with more pronounced membrane tropism. The results obtained suggest that a universal system regulating the physiological activity of cells is operative in taxonomically remote organisms. The operation of the system is based on sequential changes in the structural organization and function of subcellular structures induced by low-and high-molecular-weight autoregulators." @default.
- W2024013035 created "2016-06-24" @default.
- W2024013035 creator A5025299142 @default.
- W2024013035 creator A5028966108 @default.
- W2024013035 creator A5046724350 @default.
- W2024013035 creator A5085484250 @default.
- W2024013035 creator A5090909451 @default.
- W2024013035 date "2000-09-01" @default.
- W2024013035 modified "2023-10-04" @default.
- W2024013035 title "Effect of membrane-active microbial autoregulators on the growth of culturedras-transformed fibroblasts" @default.
- W2024013035 cites W1986472234 @default.
- W2024013035 cites W2019915161 @default.
- W2024013035 cites W2070188097 @default.
- W2024013035 cites W2088906052 @default.
- W2024013035 doi "https://doi.org/10.1007/bf02731892" @default.
- W2024013035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11042878" @default.
- W2024013035 hasPublicationYear "2000" @default.
- W2024013035 type Work @default.
- W2024013035 sameAs 2024013035 @default.
- W2024013035 citedByCount "3" @default.
- W2024013035 countsByYear W20240130352013 @default.
- W2024013035 countsByYear W20240130352021 @default.
- W2024013035 crossrefType "journal-article" @default.
- W2024013035 hasAuthorship W2024013035A5025299142 @default.
- W2024013035 hasAuthorship W2024013035A5028966108 @default.
- W2024013035 hasAuthorship W2024013035A5046724350 @default.
- W2024013035 hasAuthorship W2024013035A5085484250 @default.
- W2024013035 hasAuthorship W2024013035A5090909451 @default.
- W2024013035 hasConcept C104317684 @default.
- W2024013035 hasConcept C10879258 @default.
- W2024013035 hasConcept C154317977 @default.
- W2024013035 hasConcept C185592680 @default.
- W2024013035 hasConcept C202751555 @default.
- W2024013035 hasConcept C203014093 @default.
- W2024013035 hasConcept C2522874641 @default.
- W2024013035 hasConcept C2778976237 @default.
- W2024013035 hasConcept C28406088 @default.
- W2024013035 hasConcept C35693153 @default.
- W2024013035 hasConcept C55493867 @default.
- W2024013035 hasConcept C67705224 @default.
- W2024013035 hasConcept C86803240 @default.
- W2024013035 hasConcept C95444343 @default.
- W2024013035 hasConceptScore W2024013035C104317684 @default.
- W2024013035 hasConceptScore W2024013035C10879258 @default.
- W2024013035 hasConceptScore W2024013035C154317977 @default.
- W2024013035 hasConceptScore W2024013035C185592680 @default.
- W2024013035 hasConceptScore W2024013035C202751555 @default.
- W2024013035 hasConceptScore W2024013035C203014093 @default.
- W2024013035 hasConceptScore W2024013035C2522874641 @default.
- W2024013035 hasConceptScore W2024013035C2778976237 @default.
- W2024013035 hasConceptScore W2024013035C28406088 @default.
- W2024013035 hasConceptScore W2024013035C35693153 @default.
- W2024013035 hasConceptScore W2024013035C55493867 @default.
- W2024013035 hasConceptScore W2024013035C67705224 @default.
- W2024013035 hasConceptScore W2024013035C86803240 @default.
- W2024013035 hasConceptScore W2024013035C95444343 @default.
- W2024013035 hasIssue "5" @default.
- W2024013035 hasLocation W20240130351 @default.
- W2024013035 hasLocation W20240130352 @default.
- W2024013035 hasOpenAccess W2024013035 @default.
- W2024013035 hasPrimaryLocation W20240130351 @default.
- W2024013035 hasRelatedWork W1524333518 @default.
- W2024013035 hasRelatedWork W1966200298 @default.
- W2024013035 hasRelatedWork W1966603801 @default.
- W2024013035 hasRelatedWork W1972426848 @default.
- W2024013035 hasRelatedWork W1987454130 @default.
- W2024013035 hasRelatedWork W1989618077 @default.
- W2024013035 hasRelatedWork W2024042048 @default.
- W2024013035 hasRelatedWork W2070507086 @default.
- W2024013035 hasRelatedWork W2097519329 @default.
- W2024013035 hasRelatedWork W2335930493 @default.
- W2024013035 hasVolume "36" @default.
- W2024013035 isParatext "false" @default.
- W2024013035 isRetracted "false" @default.
- W2024013035 magId "2024013035" @default.
- W2024013035 workType "article" @default.