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• W2024014523 startingPage "669" @default.
• W2024014523 abstract "Four xanthones were isolated from Gentianopsis paludosa Ma and were identified by modern spectroscopic methods. Cytotoxicity of the four xanthones was tested on HepG2 cells and HL-60 cells by sulphorhodamine B (SRB) assay. Clonogenic survival assay, trypan blue exclusion method, AO/EB staining and DNA fragmentation assay were conducted to investigate the effect on growth inhibition and apoptosis in the two cell lines in vitro. At the same time, structure-activity relationships (SARs) of the xanthones were investigated. The results showed that the xanthones had significant cytotoxicity and inhibition of proliferation in both HepG2 cells and HL-60 cells, and could induce apoptosis in these two cell lines. SARs indicated that the methoxy group had more cytotoxic contribution than the hydroxyl group at site C-8 in the structural scaffold of xanthone. The glycosidea at site C-1 may aggravate the stereospecific blockade of compound 4 and reduced its cytotoxic activity." @default.
• W2024014523 created "2016-06-24" @default.
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• W2024014523 date "2011-04-01" @default.
• W2024014523 modified "2023-09-26" @default.
• W2024014523 title "Cytotoxicity, apoptosis-inducing effects and structure-activity relationships of four natural xanthones from<i>Gentianopsis paludosa</i>Ma in HepG2 and HL-60 cells" @default.
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• W2024014523 doi "https://doi.org/10.1080/14786410802497398" @default.
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