Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024014708> ?p ?o ?g. }
- W2024014708 endingPage "3311" @default.
- W2024014708 startingPage "3301" @default.
- W2024014708 abstract "Abstract Although the exact etiology of systemic lupus erythematosus (SLE) remains elusive, B‐cell hyperactivity and production of autoantibodies directed to components of the cell nucleus are a well‐established pathogenetic mechanism of the disease. Therefore, the targeted inhibition of DNA‐specific B cells is a logical therapeutic approach. The complement receptor type 1 (CR1, CD35) has been shown to suppress human B‐cell activation and proliferation after co‐cross‐linking with the BCR, and may serve as a mediator for negative signal delivery. In order to evaluate this therapeutic approach in a human‐like system, we used immune‐restricted SCID mice transferred with PBMCs from SLE patients. The tolerance of these humanized SCID mice to native DNA was re‐established after administration of a chimeric molecule consisting of a CR1‐specific mAb coupled to the decapeptide DWEYSVWLSN that mimics dsDNA. The generated protein‐engineered chimera was able to co‐cross‐link selectively native DNA‐specific BCR with the B‐cell inhibitory receptor CR1, thus delivering a strong inhibitory signal." @default.
- W2024014708 created "2016-06-24" @default.
- W2024014708 creator A5009373718 @default.
- W2024014708 creator A5014537906 @default.
- W2024014708 creator A5015289003 @default.
- W2024014708 creator A5018138289 @default.
- W2024014708 creator A5019030520 @default.
- W2024014708 creator A5057125321 @default.
- W2024014708 creator A5064595355 @default.
- W2024014708 creator A5068576627 @default.
- W2024014708 creator A5082134305 @default.
- W2024014708 creator A5091315212 @default.
- W2024014708 date "2011-09-28" @default.
- W2024014708 modified "2023-10-18" @default.
- W2024014708 title "Elimination of autoreactive B cells in humanized SCID mouse model of SLE" @default.
- W2024014708 cites W1218330885 @default.
- W2024014708 cites W159968576 @default.
- W2024014708 cites W1661506967 @default.
- W2024014708 cites W1755849265 @default.
- W2024014708 cites W1966157993 @default.
- W2024014708 cites W1966930760 @default.
- W2024014708 cites W1971375480 @default.
- W2024014708 cites W1975007576 @default.
- W2024014708 cites W1981610922 @default.
- W2024014708 cites W1988575100 @default.
- W2024014708 cites W1991725676 @default.
- W2024014708 cites W1997274227 @default.
- W2024014708 cites W1999800165 @default.
- W2024014708 cites W2021257197 @default.
- W2024014708 cites W2024834532 @default.
- W2024014708 cites W2035806483 @default.
- W2024014708 cites W2054922502 @default.
- W2024014708 cites W2060208115 @default.
- W2024014708 cites W2060856542 @default.
- W2024014708 cites W2069793231 @default.
- W2024014708 cites W2077570217 @default.
- W2024014708 cites W2081176141 @default.
- W2024014708 cites W2084547554 @default.
- W2024014708 cites W2086542713 @default.
- W2024014708 cites W2090520102 @default.
- W2024014708 cites W2090558865 @default.
- W2024014708 cites W2092142504 @default.
- W2024014708 cites W2095688897 @default.
- W2024014708 cites W2104646232 @default.
- W2024014708 cites W2115807207 @default.
- W2024014708 cites W2117806308 @default.
- W2024014708 cites W2126678530 @default.
- W2024014708 cites W2133764756 @default.
- W2024014708 cites W2134451223 @default.
- W2024014708 cites W2140433336 @default.
- W2024014708 cites W2145322348 @default.
- W2024014708 cites W2153705874 @default.
- W2024014708 cites W2167274549 @default.
- W2024014708 cites W2169018274 @default.
- W2024014708 cites W2172180689 @default.
- W2024014708 cites W2179862924 @default.
- W2024014708 cites W2227157639 @default.
- W2024014708 cites W2328192859 @default.
- W2024014708 cites W285394513 @default.
- W2024014708 doi "https://doi.org/10.1002/eji.201141439" @default.
- W2024014708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21830207" @default.
- W2024014708 hasPublicationYear "2011" @default.
- W2024014708 type Work @default.
- W2024014708 sameAs 2024014708 @default.
- W2024014708 citedByCount "18" @default.
- W2024014708 countsByYear W20240147082013 @default.
- W2024014708 countsByYear W20240147082014 @default.
- W2024014708 countsByYear W20240147082016 @default.
- W2024014708 countsByYear W20240147082017 @default.
- W2024014708 countsByYear W20240147082019 @default.
- W2024014708 countsByYear W20240147082020 @default.
- W2024014708 countsByYear W20240147082021 @default.
- W2024014708 countsByYear W20240147082022 @default.
- W2024014708 crossrefType "journal-article" @default.
- W2024014708 hasAuthorship W2024014708A5009373718 @default.
- W2024014708 hasAuthorship W2024014708A5014537906 @default.
- W2024014708 hasAuthorship W2024014708A5015289003 @default.
- W2024014708 hasAuthorship W2024014708A5018138289 @default.
- W2024014708 hasAuthorship W2024014708A5019030520 @default.
- W2024014708 hasAuthorship W2024014708A5057125321 @default.
- W2024014708 hasAuthorship W2024014708A5064595355 @default.
- W2024014708 hasAuthorship W2024014708A5068576627 @default.
- W2024014708 hasAuthorship W2024014708A5082134305 @default.
- W2024014708 hasAuthorship W2024014708A5091315212 @default.
- W2024014708 hasBestOaLocation W20240147081 @default.
- W2024014708 hasConcept C159654299 @default.
- W2024014708 hasConcept C163764329 @default.
- W2024014708 hasConcept C170493617 @default.
- W2024014708 hasConcept C203014093 @default.
- W2024014708 hasConcept C2776156784 @default.
- W2024014708 hasConcept C2777702733 @default.
- W2024014708 hasConcept C2778453870 @default.
- W2024014708 hasConcept C43907098 @default.
- W2024014708 hasConcept C502942594 @default.
- W2024014708 hasConcept C542903549 @default.
- W2024014708 hasConcept C54355233 @default.
- W2024014708 hasConcept C86803240 @default.
- W2024014708 hasConcept C8891405 @default.