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- W2024015458 abstract "To identify factors related to progression to CMV end-organ disease, cytokine production, proliferative capacity and phenotype of CMV-specific CD4 + T-cells were analysed longitudinally. Numbers of IFNγ + CD4 + and IFNγ + IL-2 + CD4 + T-cells tended to decrease in individuals progressing to AIDS with CMV end-organ disease (AIDS–CMV), whereas they remained detectable in long-term asymptomatics (LTAs) and progressors to AIDS with opportunistic infections (AIDS–OI). In parallel, CMV-specific proliferative capacity was lost in AIDS–CMV. Initially, the majority of the CMV-specific IFNγ + CD4 + T-cells were of the CD45RO + CD27 − subset, but during progression to AIDS–CMV a shift in phenotype to the CD45RO − CD27 − subset was observed. Our data indicate that a decrease in CMV-specific cytokine production and proliferative capacity precedes progression to AIDS–CMV. Accumulation of CD4 + T-cells with a CD45RO − CD27 − phenotype suggests that persistent antigen exposure drives differentiation of CMV-specific CD4 + T-cells towards a poorly proliferating, and highly differentiated “effector” subset, which eventually fails to produce IFNγ in patients developing AIDS–CMV." @default.
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- W2024015458 date "2007-08-01" @default.
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- W2024015458 title "Shift of CMV-specific CD4+ T-cells to the highly differentiated CD45RO−CD27− phenotype parallels loss of proliferative capacity and precedes progression to HIV-related CMV end-organ disease" @default.
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- W2024015458 doi "https://doi.org/10.1016/j.clim.2007.04.016" @default.
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