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• W2024015938 abstract "Microbial transformation of androst-4-en-3,17-dione (AD; 1) using Colletotrichum lini AS3. 4486 resulted in the production of two metabolites 2 and 3. The structures of these compounds were elucidated by spectroscopic analysis (LC-MS, FTIR and NMR) as 15α-hydroxyandrost-4-en-3,17-dione (15α-OH-AD; 2) and 11α,15α-dihydroxyandrost-4-en-3,17-dione (11α,15α-diOH-AD; 3). AD underwent regioselective hydroxylation at 15α position, subsequently hydroxylated at 11α position and converted to compound 3. 11α,15α-diOH-AD as an important metabolic product was pharmaceutical intermediate and the yield was up to 97.58% when the concentration of substrate was 4 g L -1 ." @default.
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• W2024015938 date "2014-04-01" @default.
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• W2024015938 title "Research on Biochemical Materials with Hydroxylation of Androst-4-en-3,17-dione by <i>Colletotrichum lini</i> AS3. 4486" @default.
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• W2024015938 doi "https://doi.org/10.4028/www.scientific.net/amm.540.347" @default.
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