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- W2024016078 endingPage "241" @default.
- W2024016078 startingPage "231" @default.
- W2024016078 abstract "The primary function of the epidermis is to produce the protective, semi-permeable stratum corneum that permits terrestrial life. The barrier function of the stratum corneum is provided by patterned lipid lamellae localized to the extracellular spaces between corneocytes. Anucleate corneocytes contain keratin filaments bound to a peripheral cornified envelope composed of cross-linked proteins. The many layers of these specialized cells in the stratum corneum provide a tough and resilient framework for the intercellular lipid lamellae. The lamellae are derived from disk-like lipid membranes extruded from lamellar granules into the intercellular spaces of the upper granular layer. Lysosomal and other enzymes present in the extracellular compartment are responsible for the lipid remodeling required to generate the barrier lamellae as well as for the reactions that result in desquamation. Lamellar granules likely originate from the Golgi apparatus and are currently thought to be elements of the tubulo-vesicular trans-Golgi network. The regulation of barrier lipid synthesis has been studied in a variety of models, with induction of several enzymes demonstrated during fetal development and keratinocyte differentiation, but an understanding of this process at the molecular genetic level awaits further study. Certain genetic defects in lipid metabolism or in the protein components of the stratum corneum produce scaly or ichthyotic skin with abnormal barrier lipid structure and function. The inflammatory skin diseases psoriasis and atopic dermatitis also show decreased barrier function, but the underlying mechanisms remain under investigation. Topically applied moisturizers work by acting as humectants or by providing an artificial barrier to trans-epidermal water loss; current work has focused on developing a more physiologic mix of lipids for topical application to skin. Recent studies in genetically engineered mice have suggested an unexpected role for tight junctions in epidermal barrier function and further developments in this area are expected. Ultimately, more sophisticated understanding of epidermal barrier function will lead to more rational therapy of a host of skin conditions in which the barrier is impaired." @default.
- W2024016078 created "2016-06-24" @default.
- W2024016078 creator A5013679858 @default.
- W2024016078 date "2003-08-01" @default.
- W2024016078 modified "2023-10-14" @default.
- W2024016078 title "Barrier Function of the Skin: “La Raison d'Être” of the Epidermis" @default.
- W2024016078 cites W1513329088 @default.
- W2024016078 cites W1532331610 @default.
- W2024016078 cites W1575329977 @default.
- W2024016078 cites W1577282977 @default.
- W2024016078 cites W1578395803 @default.
- W2024016078 cites W1585578035 @default.
- W2024016078 cites W1964353889 @default.
- W2024016078 cites W1965620551 @default.
- W2024016078 cites W1966721755 @default.
- W2024016078 cites W1967759078 @default.
- W2024016078 cites W1967954872 @default.
- W2024016078 cites W1972401201 @default.
- W2024016078 cites W1974994627 @default.
- W2024016078 cites W1975512501 @default.
- W2024016078 cites W1976580145 @default.
- W2024016078 cites W1976625004 @default.
- W2024016078 cites W1976938630 @default.
- W2024016078 cites W1977767522 @default.
- W2024016078 cites W1978562441 @default.
- W2024016078 cites W1978858571 @default.
- W2024016078 cites W1981925521 @default.
- W2024016078 cites W1984539685 @default.
- W2024016078 cites W1988116347 @default.
- W2024016078 cites W1988203671 @default.
- W2024016078 cites W1988967018 @default.
- W2024016078 cites W1990084557 @default.
- W2024016078 cites W1990981756 @default.
- W2024016078 cites W1991215819 @default.
- W2024016078 cites W1992560570 @default.
- W2024016078 cites W1993709743 @default.
- W2024016078 cites W1994096971 @default.
- W2024016078 cites W1996680206 @default.
- W2024016078 cites W1997219163 @default.
- W2024016078 cites W2001323678 @default.
- W2024016078 cites W2004061895 @default.
- W2024016078 cites W2005090658 @default.
- W2024016078 cites W2007350878 @default.
- W2024016078 cites W2007771721 @default.
- W2024016078 cites W2007956036 @default.
- W2024016078 cites W2008652678 @default.
- W2024016078 cites W2010213397 @default.
- W2024016078 cites W2011217639 @default.
- W2024016078 cites W2011755455 @default.
- W2024016078 cites W2012317026 @default.
- W2024016078 cites W2016161201 @default.
- W2024016078 cites W2016954164 @default.
- W2024016078 cites W2017236038 @default.
- W2024016078 cites W2018171395 @default.
- W2024016078 cites W2018832136 @default.
- W2024016078 cites W2019019958 @default.
- W2024016078 cites W2020573304 @default.
- W2024016078 cites W2020904190 @default.
- W2024016078 cites W2021532564 @default.
- W2024016078 cites W2022791658 @default.
- W2024016078 cites W2022987234 @default.
- W2024016078 cites W2023702032 @default.
- W2024016078 cites W2026275425 @default.
- W2024016078 cites W2027406450 @default.
- W2024016078 cites W2027431875 @default.
- W2024016078 cites W2028358547 @default.
- W2024016078 cites W2029373802 @default.
- W2024016078 cites W2030068752 @default.
- W2024016078 cites W2031313854 @default.
- W2024016078 cites W2031317659 @default.
- W2024016078 cites W2033921570 @default.
- W2024016078 cites W2035411151 @default.
- W2024016078 cites W2038346886 @default.
- W2024016078 cites W2039678120 @default.
- W2024016078 cites W2044052303 @default.
- W2024016078 cites W2045845920 @default.
- W2024016078 cites W2047944354 @default.
- W2024016078 cites W2048861627 @default.
- W2024016078 cites W2049192748 @default.
- W2024016078 cites W2049218114 @default.
- W2024016078 cites W2051767864 @default.
- W2024016078 cites W2052445370 @default.
- W2024016078 cites W2052947707 @default.
- W2024016078 cites W2053424720 @default.
- W2024016078 cites W2058746234 @default.
- W2024016078 cites W2059105163 @default.
- W2024016078 cites W2062277825 @default.
- W2024016078 cites W2064161616 @default.
- W2024016078 cites W2066281343 @default.
- W2024016078 cites W2066413791 @default.
- W2024016078 cites W2066639885 @default.
- W2024016078 cites W2067204579 @default.
- W2024016078 cites W2067534485 @default.
- W2024016078 cites W2069087512 @default.
- W2024016078 cites W2070935457 @default.
- W2024016078 cites W2072392419 @default.
- W2024016078 cites W2073532048 @default.
- W2024016078 cites W2075060423 @default.