Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024016832> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2024016832 endingPage "344" @default.
- W2024016832 startingPage "337" @default.
- W2024016832 abstract "Monitoring of ethane and pentane in breath as a noninvasive method to measure lipid peroxidation is performed by an increasing number of laboratories. The alkanes are generated through peroxidative breakdown of polyunsaturated fatty acids. Fasted Sprague-Dawley rats exhale these hydrocarbons at a rate of approximately 1.7 nmol/kg·hr. Through an improved analytical procedure other volatile hydrocarbons could be detected in the breath of the animals, i.e., ethene (1.1 nmol/kg·hr), propane (0.7 nmol/kg·hr), n-butane (0.7 nmol/kg·hr), iso-pentane, and iso-butene. The exhaled hydrocarbons accumulate in the atmosphere if an animal is confined in a closed system. However, the increase is not linear but a steady-state concentration is approached, presumably due to reuptake and subsequent hepatic metabolism. Hydrocarbons are oxidized by the hepatic monooxygenases, at rates increasing with their molecular masses. The same has been found for the elimination of ethane, propane, butane, pentane, and iso-butene by a rat from closed system. Metabolism is inhibited by a variety of substances, e.g., dithiocarb, ethanol, and tetrahydrofurane. Therefore, the increased release of hydrocarbons into the gas phase, after treatment with compounds suspected to induce lipid peroxidation, may merely result from decreased metabolism. Especially if the hydrocarbon exhalation is only moderately elevated as after ethanol administration, this aspect must be taken into account. Similarly, peroxidizing microsomes show elevated hydrocarbon output when treated with carbon monoxide in order to block metabolism. This study provides a procedure for discrimination of inhibitory and peroxidative action which is of particular importance if the increase over control levels is only moderate. In addition, it may serve as monitor for the metabolic capacity of a laboratory animal." @default.
- W2024016832 created "2016-06-24" @default.
- W2024016832 creator A5006223766 @default.
- W2024016832 creator A5059201156 @default.
- W2024016832 creator A5063491911 @default.
- W2024016832 creator A5083216340 @default.
- W2024016832 date "1980-12-01" @default.
- W2024016832 modified "2023-10-18" @default.
- W2024016832 title "Monitoring lipid peroxidation by breath analysis: Endogenous hydrocarbons and their metabolic elimination" @default.
- W2024016832 cites W1649204447 @default.
- W2024016832 cites W1936968156 @default.
- W2024016832 cites W1992679003 @default.
- W2024016832 cites W1992777244 @default.
- W2024016832 cites W1994175131 @default.
- W2024016832 cites W1994635899 @default.
- W2024016832 cites W1996984062 @default.
- W2024016832 cites W2000658172 @default.
- W2024016832 cites W2008255346 @default.
- W2024016832 cites W2009530426 @default.
- W2024016832 cites W2020000289 @default.
- W2024016832 cites W2022687975 @default.
- W2024016832 cites W2028387592 @default.
- W2024016832 cites W2032178118 @default.
- W2024016832 cites W2037112738 @default.
- W2024016832 cites W2039739227 @default.
- W2024016832 cites W2053266482 @default.
- W2024016832 cites W2060081825 @default.
- W2024016832 cites W2064730426 @default.
- W2024016832 cites W2069727507 @default.
- W2024016832 cites W2077136635 @default.
- W2024016832 cites W2077584311 @default.
- W2024016832 cites W2085092514 @default.
- W2024016832 cites W2098278399 @default.
- W2024016832 cites W2126803241 @default.
- W2024016832 cites W2174208829 @default.
- W2024016832 cites W2316320278 @default.
- W2024016832 cites W2328622669 @default.
- W2024016832 cites W2415135998 @default.
- W2024016832 cites W65640609 @default.
- W2024016832 doi "https://doi.org/10.1016/0041-008x(80)90066-6" @default.
- W2024016832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7222017" @default.
- W2024016832 hasPublicationYear "1980" @default.
- W2024016832 type Work @default.
- W2024016832 sameAs 2024016832 @default.
- W2024016832 citedByCount "134" @default.
- W2024016832 countsByYear W20240168322013 @default.
- W2024016832 countsByYear W20240168322016 @default.
- W2024016832 countsByYear W20240168322019 @default.
- W2024016832 countsByYear W20240168322021 @default.
- W2024016832 countsByYear W20240168322023 @default.
- W2024016832 crossrefType "journal-article" @default.
- W2024016832 hasAuthorship W2024016832A5006223766 @default.
- W2024016832 hasAuthorship W2024016832A5059201156 @default.
- W2024016832 hasAuthorship W2024016832A5063491911 @default.
- W2024016832 hasAuthorship W2024016832A5083216340 @default.
- W2024016832 hasConcept C178790620 @default.
- W2024016832 hasConcept C185592680 @default.
- W2024016832 hasConcept C2777207669 @default.
- W2024016832 hasConcept C2778004101 @default.
- W2024016832 hasConcept C2780829032 @default.
- W2024016832 hasConcept C43617362 @default.
- W2024016832 hasConcept C55493867 @default.
- W2024016832 hasConcept C62231903 @default.
- W2024016832 hasConceptScore W2024016832C178790620 @default.
- W2024016832 hasConceptScore W2024016832C185592680 @default.
- W2024016832 hasConceptScore W2024016832C2777207669 @default.
- W2024016832 hasConceptScore W2024016832C2778004101 @default.
- W2024016832 hasConceptScore W2024016832C2780829032 @default.
- W2024016832 hasConceptScore W2024016832C43617362 @default.
- W2024016832 hasConceptScore W2024016832C55493867 @default.
- W2024016832 hasConceptScore W2024016832C62231903 @default.
- W2024016832 hasIssue "3" @default.
- W2024016832 hasLocation W20240168321 @default.
- W2024016832 hasLocation W20240168322 @default.
- W2024016832 hasOpenAccess W2024016832 @default.
- W2024016832 hasPrimaryLocation W20240168321 @default.
- W2024016832 hasRelatedWork W2044612588 @default.
- W2024016832 hasRelatedWork W2046854371 @default.
- W2024016832 hasRelatedWork W2050108200 @default.
- W2024016832 hasRelatedWork W2088669026 @default.
- W2024016832 hasRelatedWork W2152342291 @default.
- W2024016832 hasRelatedWork W2317407376 @default.
- W2024016832 hasRelatedWork W2395780673 @default.
- W2024016832 hasRelatedWork W2604890884 @default.
- W2024016832 hasRelatedWork W2951455053 @default.
- W2024016832 hasRelatedWork W2995758399 @default.
- W2024016832 hasVolume "56" @default.
- W2024016832 isParatext "false" @default.
- W2024016832 isRetracted "false" @default.
- W2024016832 magId "2024016832" @default.
- W2024016832 workType "article" @default.