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• W2024018944 startingPage "2820" @default.
• W2024018944 abstract "ABSTRACT Factor C protein isolated from the horseshoe crab, Carcinoscorpius rotundicauda , has endotoxin binding capability. Synthetic peptides of 34 amino acids based on the sequence of two regions of factor C (Sushi 1 and Sushi 3) as well as their corresponding mutants exhibited activities against 30 clinical isolates of Pseudomonas aeruginosa . Collectively, all four peptides demonstrated exceptionally effective bactericidal activity against P. aeruginosa with 90% minimal bactericidal concentrations (MBC 90 s) in the range of 0.06 to 0.25 μg/ml (16 to 63 nM). Viable bacteria were reduced by 90% after 7 min and were totally eradicated within 40 to 50 min. These peptides are minimally hemolytic against both rabbit and human erythrocytes even at concentrations up to 1,600-fold their MBC 90 s. Both in vitro and in vivo studies indicate that cytotoxic effects are small even at 1,000-fold their MBC 90 s. Furthermore, the Sushi peptides are tolerant of high-salt and adverse pH conditions. These findings demonstrate the promising therapeutic potential of the Sushi peptides." @default.
• W2024018944 created "2016-06-24" @default.
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• W2024018944 date "2001-10-01" @default.
• W2024018944 modified "2023-09-30" @default.
• W2024018944 title "High Therapeutic Index of Factor C Sushi Peptides: Potent Antimicrobials against <i>Pseudomonas aeruginosa</i>" @default.
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• W2024018944 doi "https://doi.org/10.1128/aac.45.10.2820-2825.2001" @default.
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