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• W2024027093 startingPage "1557" @default.
• W2024027093 abstract "Abstract Ski8p is a 44‐kD protein that primarily functions in the regulation of exosome‐mediated, 3′→ 5′ degradation of damaged mRNA. It does so by forming a complex with two partner proteins, Ski2p and Ski3p, which complete a complex that is capable of recruiting and activating the exosome/Ski7p complex that functions in RNA degradation. Ski8p also functions in meiotic recombination in complex with Spo11 in yeast. It is one of the many hundreds of primarily eukaryotic proteins containing tandem copies of WD repeats (also known as WD40 or β‐transducin repeats), which are short ∼40 amino acid motifs, often terminating in a Trp–Asp dipeptide. Genomic analyses have demonstrated that WD repeats are found in 1%–2% of proteins in a typical eukaryote, but are extremely rare in prokaryotes. Almost all structurally characterized WD‐repeat proteins are composed of seven such repeats and fold into seven‐bladed β propellers. Ski8p was thought to contain five WD repeats on the basis of primary sequence analysis implying a five‐bladed propeller. The 1.9 Å crystal structure unexpectedly exhibits a seven‐bladed propeller fold with seven structurally authentic WD repeats. Structure‐based sequence alignments show additional sequence diversity in the two undetected repeats. This demonstrates that many WD repeats have not yet been identified in sequences and also raises the possibility that the seven‐bladed propeller may be the predominant fold for this family of proteins." @default.
• W2024027093 created "2016-06-24" @default.
• W2024027093 creator A5033039869 @default.
• W2024027093 creator A5059924773 @default.
• W2024027093 date "2004-06-01" @default.
• W2024027093 modified "2023-10-16" @default.
• W2024027093 title "The structure of Ski8p, a protein regulating mRNA degradation: Implications for WD protein structure" @default.
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• W2024027093 doi "https://doi.org/10.1110/ps.04704704" @default.
• W2024027093 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2279974" @default.
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