Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024033085> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2024033085 endingPage "578" @default.
- W2024033085 startingPage "571" @default.
- W2024033085 abstract "Large neurons from layer V in a slice preparation of cat sensorimotor cortex were impaled with microelectrodes containing KCl plus different concentrations of the Ca2+ chelator 1,2-bis(o-aminophenoxy)ethane-N,N,N',N'-tetra-acetic acid (BAPTA) or two of its derivatives. Impalement with electrodes containing high BAPTA (200 mM) quickly abolished Ca(2+)-dependent afterhyperpolarizations. Spike parameters were normal, but the usual time- and voltage-dependent rectification of subthreshold membrane potential was absent. Normally, this rectification results from activation of two voltage-gated currents, the persistent sodium current (INaP) and the hyperpolarizing inward rectifier current (Ih). Both of these currents were absent during voltage clamp with high BAPTA microelectrodes. Impalement with electrodes containing low BAPTA (2 mM) or derivatives caused a different effect. Injection of a 1-s current pulse evoked phasic firing instead of the tonic firing seen normally. Both the amplitude and the duration of the Ca(2+)-dependent afterhypolarization that followed repetitive firing were much greater than normal. The effectiveness of BAPTA derivatives in altering afterhyperpolarizations and firing properties were similar to their effectiveness in chelating Ca2+. It is assumed that the BAPTA effects result from reduction of intracellular Ca2+ concentration. Results with high BAPTA suggest that (i) both INaP and Ih require a minimal intracellular calcium concentration for normal expression, and that (ii) these voltage-gated currents may be modulated by changes in intracellular calcium concentration. Results with low BAPTA suggest that a small reduction of intracellular calcium concentration preferentially enhances a slow, Ca(2+)-dependent K+ current which then dominates the firing properties of the cell. The transformed firing properties resemble those of hippocampal pyramidal neurons.(ABSTRACT TRUNCATED AT 250 WORDS)" @default.
- W2024033085 created "2016-06-24" @default.
- W2024033085 creator A5053358064 @default.
- W2024033085 creator A5057452129 @default.
- W2024033085 creator A5078279565 @default.
- W2024033085 date "1992-04-01" @default.
- W2024033085 modified "2023-10-18" @default.
- W2024033085 title "Effects of intracellular calcium chelation on voltage-dependent and calcium-dependent currents in cat neocortical neurons" @default.
- W2024033085 cites W1827142872 @default.
- W2024033085 cites W189996834 @default.
- W2024033085 cites W1966559768 @default.
- W2024033085 cites W1975931806 @default.
- W2024033085 cites W2025321443 @default.
- W2024033085 cites W2027458586 @default.
- W2024033085 cites W2036117243 @default.
- W2024033085 cites W2037622734 @default.
- W2024033085 cites W2038760179 @default.
- W2024033085 cites W2040336234 @default.
- W2024033085 cites W2041629506 @default.
- W2024033085 cites W2042224433 @default.
- W2024033085 cites W2048528277 @default.
- W2024033085 cites W2049724011 @default.
- W2024033085 cites W2058449890 @default.
- W2024033085 cites W2061260058 @default.
- W2024033085 cites W2061270861 @default.
- W2024033085 cites W2061724716 @default.
- W2024033085 cites W2074769517 @default.
- W2024033085 cites W2084647496 @default.
- W2024033085 cites W2139954402 @default.
- W2024033085 cites W2219473100 @default.
- W2024033085 cites W2299490191 @default.
- W2024033085 cites W2396331417 @default.
- W2024033085 cites W2403611111 @default.
- W2024033085 cites W59136502 @default.
- W2024033085 cites W70522370 @default.
- W2024033085 doi "https://doi.org/10.1016/0306-4522(92)90166-y" @default.
- W2024033085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1316566" @default.
- W2024033085 hasPublicationYear "1992" @default.
- W2024033085 type Work @default.
- W2024033085 sameAs 2024033085 @default.
- W2024033085 citedByCount "105" @default.
- W2024033085 countsByYear W20240330852012 @default.
- W2024033085 countsByYear W20240330852013 @default.
- W2024033085 countsByYear W20240330852015 @default.
- W2024033085 countsByYear W20240330852016 @default.
- W2024033085 countsByYear W20240330852019 @default.
- W2024033085 crossrefType "journal-article" @default.
- W2024033085 hasAuthorship W2024033085A5053358064 @default.
- W2024033085 hasAuthorship W2024033085A5057452129 @default.
- W2024033085 hasAuthorship W2024033085A5078279565 @default.
- W2024033085 hasConcept C100837961 @default.
- W2024033085 hasConcept C12554922 @default.
- W2024033085 hasConcept C169760540 @default.
- W2024033085 hasConcept C178790620 @default.
- W2024033085 hasConcept C181080969 @default.
- W2024033085 hasConcept C181911157 @default.
- W2024033085 hasConcept C185592680 @default.
- W2024033085 hasConcept C18699975 @default.
- W2024033085 hasConcept C2780019300 @default.
- W2024033085 hasConcept C519063684 @default.
- W2024033085 hasConcept C55493867 @default.
- W2024033085 hasConcept C79879829 @default.
- W2024033085 hasConcept C86803240 @default.
- W2024033085 hasConceptScore W2024033085C100837961 @default.
- W2024033085 hasConceptScore W2024033085C12554922 @default.
- W2024033085 hasConceptScore W2024033085C169760540 @default.
- W2024033085 hasConceptScore W2024033085C178790620 @default.
- W2024033085 hasConceptScore W2024033085C181080969 @default.
- W2024033085 hasConceptScore W2024033085C181911157 @default.
- W2024033085 hasConceptScore W2024033085C185592680 @default.
- W2024033085 hasConceptScore W2024033085C18699975 @default.
- W2024033085 hasConceptScore W2024033085C2780019300 @default.
- W2024033085 hasConceptScore W2024033085C519063684 @default.
- W2024033085 hasConceptScore W2024033085C55493867 @default.
- W2024033085 hasConceptScore W2024033085C79879829 @default.
- W2024033085 hasConceptScore W2024033085C86803240 @default.
- W2024033085 hasIssue "3" @default.
- W2024033085 hasLocation W20240330851 @default.
- W2024033085 hasLocation W20240330852 @default.
- W2024033085 hasOpenAccess W2024033085 @default.
- W2024033085 hasPrimaryLocation W20240330851 @default.
- W2024033085 hasRelatedWork W1520756199 @default.
- W2024033085 hasRelatedWork W1939061032 @default.
- W2024033085 hasRelatedWork W2013520840 @default.
- W2024033085 hasRelatedWork W2015979114 @default.
- W2024033085 hasRelatedWork W2027620630 @default.
- W2024033085 hasRelatedWork W2046993052 @default.
- W2024033085 hasRelatedWork W2062137316 @default.
- W2024033085 hasRelatedWork W2086341327 @default.
- W2024033085 hasRelatedWork W2090803944 @default.
- W2024033085 hasRelatedWork W2418520519 @default.
- W2024033085 hasVolume "47" @default.
- W2024033085 isParatext "false" @default.
- W2024033085 isRetracted "false" @default.
- W2024033085 magId "2024033085" @default.
- W2024033085 workType "article" @default.