Matches in SemOpenAlex for { <https://semopenalex.org/work/W2024042905> ?p ?o ?g. }
- W2024042905 endingPage "404" @default.
- W2024042905 startingPage "397" @default.
- W2024042905 abstract "Activation of protein kinase A (cAMP-dependent protein kinase; PKA) triggers insulin secretion in the beta-cell. Adenylate cyclase toxin (ACT), a bacterial exotoxin with adenylate cyclase activity, and forskolin, an activator of adenylate cyclase, both dose-dependently increased insulin secretion in the presence, but not the absence, of glucose in insulin-secreting betaTC3 cells. The stimulation of cAMP release by either agent was dose-dependent but glucose-independent. Omission of extracellular Ca(2+) totally abolished the effects of ACT on insulin secretion and cytosolic cAMP accumulation. ACT and forskolin caused rapid and dramatic increases in cytosolic Ca(2+), which were blocked by nifedipine and the omission of extracellular Ca(2+). Omission of glucose completely blocked the effects of forskolin and partially blocked the effects of ACT on cytosolic Ca(2+). PKA alpha, beta and gamma catalytic subunits (Calpha, Cbeta and Cgamma respectively) were identified in betaTC6 cells by confocal microscopy. Glucose and glucagon-like polypeptide-1 (GLP-1) caused translocation of Calpha to the nucleus and of Cbeta to the plasma membrane and the nucleus, but did not affect the distribution of Cgamma. In conclusion, glucose and GLP-1 amplify insulin secretion via cAMP production and PKAbeta activation." @default.
- W2024042905 created "2016-06-24" @default.
- W2024042905 creator A5002889060 @default.
- W2024042905 creator A5025157562 @default.
- W2024042905 creator A5026286216 @default.
- W2024042905 creator A5040686884 @default.
- W2024042905 creator A5050182252 @default.
- W2024042905 creator A5055190444 @default.
- W2024042905 creator A5085490758 @default.
- W2024042905 date "2002-12-01" @default.
- W2024042905 modified "2023-10-16" @default.
- W2024042905 title "Protein kinase A translocation and insulin secretion in pancreatic β-cells: studies with adenylate cyclase toxin from Bordetella pertussis" @default.
- W2024042905 cites W1492682055 @default.
- W2024042905 cites W1514133366 @default.
- W2024042905 cites W1572748850 @default.
- W2024042905 cites W1643127595 @default.
- W2024042905 cites W1882410298 @default.
- W2024042905 cites W1968720990 @default.
- W2024042905 cites W1969286439 @default.
- W2024042905 cites W196960734 @default.
- W2024042905 cites W1970382630 @default.
- W2024042905 cites W1970958676 @default.
- W2024042905 cites W1980391968 @default.
- W2024042905 cites W1982990627 @default.
- W2024042905 cites W1986804446 @default.
- W2024042905 cites W1989092000 @default.
- W2024042905 cites W1991848000 @default.
- W2024042905 cites W1992968276 @default.
- W2024042905 cites W1995245595 @default.
- W2024042905 cites W1998183313 @default.
- W2024042905 cites W2005975977 @default.
- W2024042905 cites W2008411184 @default.
- W2024042905 cites W2015813060 @default.
- W2024042905 cites W2020084328 @default.
- W2024042905 cites W2025659430 @default.
- W2024042905 cites W2050046962 @default.
- W2024042905 cites W2055031444 @default.
- W2024042905 cites W2067388503 @default.
- W2024042905 cites W2075242060 @default.
- W2024042905 cites W2076477984 @default.
- W2024042905 cites W2078849651 @default.
- W2024042905 cites W2081924677 @default.
- W2024042905 cites W2082036487 @default.
- W2024042905 cites W2083584165 @default.
- W2024042905 cites W2087584313 @default.
- W2024042905 cites W2089093263 @default.
- W2024042905 cites W2091044838 @default.
- W2024042905 cites W2092162739 @default.
- W2024042905 cites W2093171963 @default.
- W2024042905 cites W2110166408 @default.
- W2024042905 cites W2134736486 @default.
- W2024042905 cites W2141524439 @default.
- W2024042905 cites W2160512343 @default.
- W2024042905 cites W2171404549 @default.
- W2024042905 cites W2176176727 @default.
- W2024042905 cites W2267629923 @default.
- W2024042905 cites W2404966129 @default.
- W2024042905 cites W30701984 @default.
- W2024042905 cites W4322388712 @default.
- W2024042905 doi "https://doi.org/10.1042/bj20020999" @default.
- W2024042905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1223000" @default.
- W2024042905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12180908" @default.
- W2024042905 hasPublicationYear "2002" @default.
- W2024042905 type Work @default.
- W2024042905 sameAs 2024042905 @default.
- W2024042905 citedByCount "27" @default.
- W2024042905 countsByYear W20240429052012 @default.
- W2024042905 countsByYear W20240429052013 @default.
- W2024042905 countsByYear W20240429052014 @default.
- W2024042905 countsByYear W20240429052017 @default.
- W2024042905 countsByYear W20240429052018 @default.
- W2024042905 countsByYear W20240429052019 @default.
- W2024042905 countsByYear W20240429052020 @default.
- W2024042905 countsByYear W20240429052023 @default.
- W2024042905 crossrefType "journal-article" @default.
- W2024042905 hasAuthorship W2024042905A5002889060 @default.
- W2024042905 hasAuthorship W2024042905A5025157562 @default.
- W2024042905 hasAuthorship W2024042905A5026286216 @default.
- W2024042905 hasAuthorship W2024042905A5040686884 @default.
- W2024042905 hasAuthorship W2024042905A5050182252 @default.
- W2024042905 hasAuthorship W2024042905A5055190444 @default.
- W2024042905 hasAuthorship W2024042905A5085490758 @default.
- W2024042905 hasBestOaLocation W20240429052 @default.
- W2024042905 hasConcept C126322002 @default.
- W2024042905 hasConcept C134018914 @default.
- W2024042905 hasConcept C170493617 @default.
- W2024042905 hasConcept C180526460 @default.
- W2024042905 hasConcept C181199279 @default.
- W2024042905 hasConcept C184235292 @default.
- W2024042905 hasConcept C24998067 @default.
- W2024042905 hasConcept C2778563252 @default.
- W2024042905 hasConcept C2779276759 @default.
- W2024042905 hasConcept C2779306644 @default.
- W2024042905 hasConcept C2780069284 @default.
- W2024042905 hasConcept C28406088 @default.
- W2024042905 hasConcept C49039625 @default.
- W2024042905 hasConcept C49773422 @default.
- W2024042905 hasConcept C55493867 @default.