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• W2024042907 abstract "To reverse the profile of abnormal intracortical excitability in patients with ALS by administering drugs that promote GABAergic transmission.Transcranial magnetic stimulation (TMS) has revealed abnormalities of cortical inhibition in ALS, a reduction of the silent period, and the absence of intracortical inhibition normally occurring in response to paired TMS. Impaired inhibitory transmission could play a role in the physiopathology of this illness.Using paired TMS with conditioning stimuli from 1-to-6-msec-interstimulus intervals, we investigated 16 patients with ALS. The protocol included: (1) the drug-free profile of paired TMS; (2) paired TMS 30 minutes after the intake of diazepam (3.5 mg); (3) paired TMS after 3 weeks' treatment with gabapentin (GBP) (600 mg/day) or riluzole (50 mg/twice a day).Intracortical inhibition is lost in patients with ALS, and this abnormal profile is reversed by diazepam or sustained treatment with GBP. We also noted that motor-evoked potential amplitudes to single stimuli increased (p<0.01) after diazepam and GBP.The demonstration of pharmacologic reversal of hyperexcitability in patients with ALS makes a potentially significant contribution toward understanding the pathophysiology of a disease that has so far eluded an effective cure." @default.
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• W2024042907 date "2000-01-11" @default.
• W2024042907 modified "2023-09-23" @default.
• W2024042907 title "Pharmacologic reversal of cortical hyperexcitability in patients with ALS" @default.
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• W2024042907 doi "https://doi.org/10.1212/wnl.54.1.58" @default.
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