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- W2024043645 abstract "Exposure of eukaryotic cells to elevated temperature leads to profound switches in cell metabolism and gene expression which may be involved in cellular homeostatic mechanisms. We have investigated the effect of heat shock (45°C) on the metabolism of the phosphoinositides, a class of phospholipids involved in the function of Ca2+-linked membrane receptors. Heat shock led to stimulation of phosphoinositide turnover in HA1-CHO and Balb C 3T3 cells, resulting in the rapid accumulation of inositol trisphosphate (lP3). Mitogenic and α1 adrenergic stimulation, with serum or phenylephrine, led to similar increases in lP3. Heat shock also caused rapid increase in phosphorylation of polyphosphoinositides (PPl). Prolonged exposure to heat >15 min at 45°C led to progressive cellular toxicity which was associated with depletion of PPl. This decline in PPl concentration appeared to result from inhibition of PPl resynthesis. In this respect, heat may resemble some other types of cellular stresses in stimulating membrane phospholipases to deplete classes of membrane phospholipids. The induction of PPl turnover may, therefore, be involved in both plelotropic responses to brief heat shock and toxicity resulting from prolonged thermal stress." @default.
- W2024043645 created "2016-06-24" @default.
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- W2024043645 creator A5018799755 @default.
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- W2024043645 date "1987-03-01" @default.
- W2024043645 modified "2023-10-18" @default.
- W2024043645 title "Heat stress stimulates inositol trisphosphate release and phosphorylation of phosphoinositides in CHO and Balb C 3T3 cells" @default.
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- W2024043645 doi "https://doi.org/10.1002/jcp.1041300309" @default.
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