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- W2024052406 abstract "Case report. Johns Hopkins University School of Medicine, Baltimore, MD, USA. Sarcoidosis is a multi-system granulomatous disease of unknown etiology with worldwide distribution. The involvement of the nervous system is common—neurosarcoidosis. Immune responses play an important role in the inflammatory process and granuloma formation. We report a case of neurosarcoidosis that was refractory to two courses of intravenous steroids. Upon initiation of oral thalidomide, the patient showed dramatic improvement clinically and on magnetic resonance imaging. Thalidomide is an immunomodulatory agent that acts to inhibit production of tumor-necrosis factor-α (TNF-α), an important mediator in CNS inflammation, by enhancing TNF-α mRNA degradation. Corticosteroids have been the mainstay of treatment of neurosarcoidosis with success at halting progression of the immune process in 50% cases. Thalidomide offers unique opportunities at managing CNS inflammation due to neurosarcoidosis. None." @default.
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- W2024052406 date "2007-08-21" @default.
- W2024052406 modified "2023-10-16" @default.
- W2024052406 title "Thalidomide for acute treatment of neurosarcoidosis" @default.
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- W2024052406 doi "https://doi.org/10.1038/sj.sc.3102115" @default.
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